Seidel et al., " Pharmaceutical intervention in the JAK/STAT signaling pathway, " Oncogene 19 :2645-2656 (2000).Seidel HM, Lamb P, Rosen J. Pharmaceutical intervention in the JAK/STAT signaling path- way. Oncogene 2000; 19: 2645-2656....
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis, immune balance, tissue homeostasis, and surveill...
Negative Regulation of the JAK/STAT Signaling PathwayJoanne L. EylesDouglas J. HiltonHandbook of Cell SignalingEyles, Joanne L., and Douglas J. Hilton. 2003. "Negative Regulation of the JAK/STAT Signaling Pathway." In Handbook of Cell Signaling, 431-40....
In innate immunity, JAK/STAT signaling has been shown to mediate several processes including the activation of neutrophils and macrophages, the regulation of inflammatory responses as well as the wound repair [1], [2]. In mammals, the core components of JAK/STAT signaling pathway contain a wide...
Cytokines and growth factors play important roles in regulating cell growth, differentiation and function. The JAK-STAT signaling pathway is the major pathway f...
Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells Guonan Lin1,, Na Xu1,2, and Rongwen Xi1,* 1 National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing ...
Timeline for milestones in the JAK-STAT signaling pathway: from fundamental research to therapeutic applications. Abbreviations: IL interleukin; ISG interferon-stimulated gene; TYK tyrosine kinase; ISGF interferon-stimulated gene factor; IRF interferon regulatory factor; SCID severe combined immunodeficiency;...
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to transcription factors that bind target gene promoters in the nucleus. This process provides a mechanism for ...
Binding of IFN-β to its receptor leads to an activation of the JAK/STAT signaling pathway, which results in c-fos inhibition causing a suppression of osteoclast differentiation and osteoclastogenesis [28]. As both osteoblasts and osteoclasts are involved in the pathogenesis of osteoporosis, we ...
Binding of IFN-β to its receptor leads to an activation of the JAK/STAT signaling pathway, which results in c-fos inhibition causing a suppression of osteoclast differentiation and osteoclastogenesis [28]. As both osteoblasts and osteoclasts are involved in the pathogenesis of osteoporosis, we ...