The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various...
The JAK/STAT signaling pathway is the primary signaling mechanism for a wide array of cytokines and growth factors. It consists of four JAK (JAK1, JAK2, JAK3 and Tyk2) and seven STAT (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6) family members. This pathway is involved in...
Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal transduction cascades. Almost 40 cytokine... Murray,J P. - 《Journal of Immunology》 被引量: 1768发表: 2007年 The JAK-STAT Pathway The JAK-STAT pathway is one of the central ...
Objective To explore the inflammatory response of microglia induced by β-amyloid(Aβ) oligomers through the receptor for advanced glycation end product(RAGE),and to further analyze the relationship between the Janus kinase/signal transducer and activator of transcription(JAK /STAT) signaling pathway an...
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment. Various cytokines, i
The cross-talk between the JAK–STAT pathway and other signalling pathways has an important role in regulating immune cells. Abstract The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. ...
Huwyler, Selective stimulation of the JAK/ STAT signaling pathway by silica nanoparticles in human endothelial cells, Toxicol. In Vitro 42 (2017) 308-318.Siegrist S, Kettiger H, Fasler-Kan E, Huwyler J. Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human ...
JAK-STAT pathway is provoked in two ways: 1. Canonical pathway: It is activated by receptor binding to the ligand and are inactivated by negative regulators such as SOCS and SHPs. It is a conventional pathway that other signaling molecules are involved in, including PI3 kinase (PI3K), Mitoge...
2007. JAK-STAT sig- naling pathways are activated in the brain following reovirus infection. J. Neurovirol. 13:373-383.Goody RJ, Beckham JD, Rubtsova K, Tyler KL. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neurovirol. 2007; 13 :373–383....
Here we review recent advances in Jak–STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention, as well as broader principles of gene regulation and signal-dependent TFs.This is a preview of subscription content, access via your institution ...