The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various...
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis, immune balance, tissue homeostasis, and surveill...
Morgan Bldg., Lexington, KY 40506 , USA The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the...
New data suggests that SOCS proteins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated STATs that alters downstream gene activation. 展开 关键词: jak-stat signaling integration DOI: 10.4049/jimmunol.178.5.2623 被引量: 1768 ...
The cross-talk between the JAK–STAT pathway and other signalling pathways has an important role in regulating immune cells. Abstract The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. ...
Timeline for milestones in the JAK-STAT signaling pathway: from fundamental research to therapeutic applications. Abbreviations: IL interleukin; ISG interferon-stimulated gene; TYK tyrosine kinase; ISGF interferon-stimulated gene factor; IRF interferon regulatory factor; SCID severe combined immunodeficiency;...
JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neuro-Oncol. 2007;13(4):373-83.Goody, RJ, Beckham, JD, Rubtsova, K, Tyler, KL (2007) JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neurovirol 13: pp. 373-383...
Autosomal dominant polycystic kidney disease, characterized by cysts in the kidney and other organs, is caused by mutations in genes that encode two unrelated and quite distinct transmembrane proteins, polycystin-1 and 2. Polycystin-1 is a large (4302 amino acids) glycoprotein of unknown function...
Negative Regulation of the JAK/STAT Signaling PathwayJoanne L. EylesDouglas J. HiltonHandbook of Cell SignalingEyles, Joanne L., and Douglas J. Hilton. 2003. "Negative Regulation of the JAK/STAT Signaling Pathway." In Handbook of Cell Signaling, 431-40....
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment. Various cytokines, i