ferroptosis, its pathological roles, and its regulation during disease progression. Focusing on the use of chemical tools that target ferroptosis in preclinical studies, we also summarize recent advances in targeting ferroptosis across the growing spectrum of ferroptosis-associated pathogenic conditions. Fina...
D. Chemical basis for deuterium labeling of fat and NADPH. J. Am. Chem. Soc. 139, 14368–14371 (2017). Article CAS Google Scholar Shreve, D. S. & Levy, H. R. Kinetic mechanism of glucose-6-phosphate dehydrogenase from the lactating rat mammary gland. Implications for regulation. J....
ALI, COPD, PF, asthma, and infections [14,15,16,17,18,19]. Studies have found that the ferroptosis inhibitor ferrostatin-1 can prevent pneumonia caused by P. aeruginosa (PAO1) infection [20]. In addition, PAO1 increases the mortality of irradiated mice by inhibiting the host anti...
Among the agents showing preliminary anti-senescence effects were GSE, quercetin, fisetin, curcumin and piperlongumine (Extended Data Fig.1d,e). Quercetin and fisetin share similar chemical structures, exert similar medicinal effects and are both known senolytics11,20,21. Curcumin and piperlongumine are...
2.14. Chemical modulation of ferroptosis The ferroptosis inhibitor ferrostatin-1 [35] (Fer-1; Merck), the iron chelator deferoxamine mesylate (DFO; Merck), the iron donating compound ferric ammonium citrate (FAC; Merck), the iNOS inhibitor Nω-nitro-L-arginine (L-NOARG; Sigma-Aldrich) and ...
As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which is different from other regulated cell death forms morphologically, biochemically, and immunologically. Ferroptosis is regulated by iron metabolism, lipid metabolism, and antiox...
Additionally, exposure to mifepristone downregulated the expression of several apoptotic genes, including BIRC5 and HELLS, while increased the expression of SLC7A11, a transporter involved in ferroptosis, an iron-dependent cell death that has been shown to be regulated in PDAC and other cancers [47...
The vast majority of literature pertaining to iron and cellular senescence focuses on the distinct accumulation of iron and iron dyshomeostasis in senescent cells [208,209,210]. As such, many studies have begun targeting these iron features for senolytic drugs, particularly inducing ferroptosis [211...
elegans. The authors suggest that part of this mechanism involves the mitigation of ferroptosis, a type of non-apoptotic cell death triggered by iron-induced lipid peroxidation. This mitigation occurs through interactions with various essential components of ferroptosis and is likely facilitated by the ...
The pathophysiological role of COX-2 expression was analyzed in studies in which its activity was reduced by chemical inhibitors or by using knockout mouse models. However, very few studies have investigated the effects of the constitutive hepatic expression of COX-2. We generated a transgenic (...