Publisher Correction: The chemical basis of ferroptosisAn amendment to this paper has been published and can be accessed via a link at the top of the paper.doi:10.1038/s41589-019-0434-zMarcus ConradDerek A. PrattSpringer NatureNature Chemical Biology...
ferroptosis, its pathological roles, and its regulation during disease progression. Focusing on the use of chemical tools that target ferroptosis in preclinical studies, we also summarize recent advances in targeting ferroptosis across the growing spectrum of ferroptosis-associated pathogenic conditions. Fina...
Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free iron ions and lipid peroxidation, its importance for cancer treatment is gradually being recognized. Research on the anti-cancer mechanism of juglone is accumulating. However, the specific mechanism by which it directs ...
ALI, COPD, PF, asthma, and infections [14,15,16,17,18,19]. Studies have found that the ferroptosis inhibitor ferrostatin-1 can prevent pneumonia caused by P. aeruginosa (PAO1) infection [20]. In addition, PAO1 increases the mortality of irradiated mice by inhibiting the host anti...
(QVD-OPh). The ability of PCC1 to kill senescent cells was reversed by QVD-OPh. PCC1 thus shares its caspase-dependent induction of apoptosis as a senolytic feature with ABT-263 (Fig.2j). Further analysis with chemical inhibitors excluded PCC1-induced cell death through ferroptosis, ...
Synthetic vectors for activating the driving axis of ferroptosis Article Open access 10 September 2024 Introduction There has been interest over many decades in the use of vanadium-derived complexes as pharmacological agents to treat human disease, most notably in diabetes and cancer. There are numer...
In defence of ferroptosis Francesca Alves Darius Lane Scott Ayton Signal Transduction and Targeted Therapy(2025) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids Zhengfang Chen
Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism and contributes to ferroptosis resistance. A metabolic drug
2.14. Chemical modulation of ferroptosis The ferroptosis inhibitor ferrostatin-1 [35] (Fer-1; Merck), the iron chelator deferoxamine mesylate (DFO; Merck), the iron donating compound ferric ammonium citrate (FAC; Merck), the iNOS inhibitor Nω-nitro-L-arginine (L-NOARG; Sigma-Aldrich) and ...
smaller chemical compound with retained pharmacological properties but notably different chemical traits [55]. The combined agents might hold onto the functional properties of one or both of the overlapping drugs [54]. Also, this strategy can lead to a resulting compound with reduced molecular weight...