Publisher Correction: The chemical basis of ferroptosisCancerCell deathLipidsSmall moleculesAn amendment to this paper has been published and can be accessed via a link at the top of the paper.doi:10.1038/s41589-019-0434-zMarcus ConradDerek A. PrattSpringer NatureNature Chemical Biology...
Lipid peroxidation underlies the mechanism of oxidative cell death now known as ferroptosis. This modality, distinct from other forms of cell death, has been intensely researched in recent years owing to its relevance in both degenerative disease and can
ferroptosis, its pathological roles, and its regulation during disease progression. Focusing on the use of chemical tools that target ferroptosis in preclinical studies, we also summarize recent advances in targeting ferroptosis across the growing spectrum of ferroptosis-associated pathogenic conditions. Fina...
2,3,4Ferroptosis was first reported in 2012 and was found to be induced by erastin, an oncogenic RAS-selective lethal chemical.4Ferroptosis was officially identified as a non-apoptotic
Hyperactivated glycolysis is a metabolic hallmark of most cancer cells. Although sporadic information has revealed that glycolytic metabolites possess nonmetabolic functions as signaling molecules, how these metabolites interact with and functionally reg
Cardiovascular diseases (CVDs) are the main diseases that endanger human health, and their risk factors contribute to high morbidity and a high rate of hospitalization. Cell death is the most important pathophysiology in CVDs. As one of the cell death mechanisms, ferroptosis is a new form of re...
2.14. Chemical modulation of ferroptosis The ferroptosis inhibitor ferrostatin-1 [35] (Fer-1; Merck), the iron chelator deferoxamine mesylate (DFO; Merck), the iron donating compound ferric ammonium citrate (FAC; Merck), the iNOS inhibitor Nω-nitro-L-arginine (L-NOARG; Sigma-Aldrich) and ...
(QVD-OPh). The ability of PCC1 to kill senescent cells was reversed by QVD-OPh. PCC1 thus shares its caspase-dependent induction of apoptosis as a senolytic feature with ABT-263 (Fig.2j). Further analysis with chemical inhibitors excluded PCC1-induced cell death through ferroptosis, ...
In defence of ferroptosis Francesca Alves Darius Lane Scott Ayton Signal Transduction and Targeted Therapy(2025) Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids Zhengfang Chen
Synthetic vectors for activating the driving axis of ferroptosis Article Open access 10 September 2024 Introduction There has been interest over many decades in the use of vanadium-derived complexes as pharmacological agents to treat human disease, most notably in diabetes and cancer. There are numer...