BSO inhibits GSH synthesis with decreased GPX activity and increased ROS levels, which results in ferroptosis in Ras-mutated cells.6 Cell Death and Differentiation Process and function of ferroptosis Y Xie et al 374 Acetaminophen. The reactive metabolite of acetaminophen has been identified as N-...
Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis. Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway and the intrinsic or ...
Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369–79. Article CAS PubMed PubMed Central Google Scholar Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. ...
Ferroptosis: process and function Cell Death Differ., 23 (2016), pp. 369-379 CrossrefView in ScopusGoogle Scholar Yang et al., 2016 W.S. Yang, K.J. Kim, M.M. Gaschler, M. Patel, M.S. Shchepinov, B.R. Stockwell Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ...
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene ex...
Ferroptosis: process and function. Cell Death & Differentiation. 2016;23(3):369–79. https://doi.org/10.1038/cdd.2015.158. Article CAS Google Scholar Haase VH. Hypoxic regulation of erythropoiesis and iron metabolism. American journal of physiology Renal physiology. 2010;299(1):F1–13. https...
Regulated cell death is vital for maintaining homeostasis. In the immune system, ferroptosis is essential. The immune system is divided into two parts: inherent immunity and adaptive immunity. Ferroptosis can contribute to the immune process by influencing the quantity and function of immune cells. ...
During the process of renal injury, in addition to the classical abnormal regulation of iron metabolism and lipid peroxidation, a growing number of novel metabolic pathways have also been uncovered in ferroptosis, such as the system Xc-/glutathione peroxidase 4 (GPX4) system, ferroptosis suppressor ...
The peroxidation of unsaturated fatty acids and the catalysis of iron are the initiating factors for the production of ROS, and the application of EF24 promotes the formation of ROS while Ferrostatin-1 and Liproxstatin-1 suppress this process. In addition, the GPX4 pathway, which is essential ...
To gain a deeper comprehension of the function and operation of Sch A/5-Fu in ferroptosis, an examination was conducted on iron buildup, lipid peroxidation and GSH level. Notably, the combination of Sch A and 5-Fu resulted in a significant elevation of intracellular lipid peroxidation levels ...