This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association with several pathways, including iron, lipid, and cysteine metabolism. We have further discussed the contribution of ferroptosis to the pathogenesis of several diseases such as cancer, ischemia/...
DiseasesFerroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, ...
2,3,4]. Ferroptosis is a recently discovered iron-dependent regulated cell death mode that is distinguished from other regulated cell death modes by the accumulation of lipid hydroperoxides and the distinct mechanism [5,6].
and iron metabolism through the transcriptional upregulation of multiple genes, including heme oxygenase 1 (HMOX1/HO1) (Fig.5a, b). However, HMOX1 plays a dual role in ferroptosis.33,39This dual mechanism of protection versus cytotoxicity of HMOX1 was already proposed in 1999.54Ferroptosis ...
This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association with several pathways, including iron, lipid, and cysteine metabolism. We have further discussed the contribution of ferroptosis to the pathogenesis of several diseases such as cancer, ischemia/...
3. Molecular mechanism of ferroptosis 3.1. Iron metabolism and ferroptosis Iron is a crucial trace element within the human body, playing a significant role in various physiological processes such as DNA, RNA, and protein synthesis, oxygen transportation, cell differentiation, and proliferation (Reicher...
2. Ferroptosis mechanism 3. The role of ferroptosis in DLBCL 4. Interventions targeting ferroptosis in DLBCL 5. Conclusions and perspectives Ethics approval and consent to participate Funding CRediT authorship contribution statement Declaration of Competing Interest Acknowledgments Data availability ReferencesSho...
Mechanism of ferroptosis Regulation of intracellular iron homeostasis Iron is a transition metal that is a basic component of almost all living cells and organisms. It is a component of a variety of metal proteins, involved in tissue oxygen transport, mitochondrial respiratory electron transfer reaction...
Mechanism of ferroptotic cell death. System xc- transports intracellular Glu to the extracellular space and extracellular Cys2 into the cell, which is then transformed into Cys for GSH synthesis. GPX4 reduces the endogenous neutralization of PUFAs-OOH to PUFAs-OH, ultimately reducing ROS accumulati...
In a review titled "The Mechanism of Ferroptosis and its Related Diseases," Feng and his colleagues from the Department of Urology and the Institute of Urology, State Key Laboratory of Biotherapy, and Cancer Center at West China Hospital, Sichuan University, have undertaken a comprehensive investiga...