However, the systemic association of ferroptosis and cardiomyopathy remains largely unknown and needs to be elucidated. In this review, we provide an overview of the molecular mechanisms of ferroptosis and its role in individual cardiomyopathies, highlight that targeting ferroptosis maybe a potential ...
Unsaturated fatty acids play a major role in cell membrane lipid peroxidation, which is driven by free radicals, and its products increase during ferroptosis. PUFA peroxidation is crucial for ferroptosis despite the fact that a variety of cell membrane lipids may undergo oxidation [26,27]. Long-c...
By understanding the molecular mechanisms underlying ferroptosis and its role in neurodegeneration, researchers can develop novel therapeutic strategies to halt or slow down the progression of ALS. Additionally, identifying specific biomarkers associated with ferroptosis in ALS patients could lead to more ...
Chronic kidney disease (CKD) has historically been a significant global health concern, profoundly impacting both life and well-being. In the process of CKD, with the gradual loss of renal function, the incidence of various life-threatening complications, such as cardiovascular diseases, cerebrovascula...
Ferroptosis has emerged as a potential key player in various diseases and the initiation of organ fibrosis. Substantial evidence suggests that ferroptosis may significantly contribute to the intricate interplay between CKD and its progression. This review comprehensively outlines the intricate relati...
The role of Q10 engineering mesenchymal stem cell-derived exosomes in inhibiting ferroptosis for diabetic wound healing BACKGROUND. Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting its potential as a therapeutic target. Ste... R Yang,S Zhou,J Huang...
The powerful symptomatic action and short half-life of L-DOPA also weakens its clinical use with motor complications such as “wearing off” and dyskinesia occurring 4-6 years after chronic use, depending on disease severity (Agid et al., 1998; Agid et al., 2002; Tran et al., 2018)....
confirmed that ferroptosis is associated with the development of diverse CVDs and may be a potential therapeutic drug target for CVDs. In this review, we summarize the characteristics and related mechanisms of ferroptosis and focus on its role in CVDs, with the goal of inspiring novel treatment ...
report the induction of Acod1 in tumor-infiltrating neutrophils (TINs) and its critical role in blunting ferroptosis and sustaining viability for TINs. Acod1 ablation abates TIN density, constrains breast cancer metastasis, bolsters antitumor Tcell immunity, and boosts the the anti-metastasis ...
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body’s immune system. This review provides an overview...