In addition, interventions targeting ferroptosis can influence the course of NDD, making it a potential therapeutic target for NDD. By summarizing the current research on ferroptosis and its impact on many neurological diseases, we hope to provide valuable strategies for the underlying mechanisms and ...
This neurologic phenotype is similar to Friedreich's ataxia, a genetic neurological disorder reportedly linked to ferroptosis [155], suggesting that endogenous vitamin E plays a preventive role against neuronal ferroptosis. Mouse chow pellets commonly contain physiologically high levels of vitamin E, with...
In addition, regarding ferroptosis is a newly discovered form of regulated cell death, many of its physiological and pathophysiological roles yet to be defined. The overall mechanisms of ferroptosis in neurological diseases are still elusive, and may involve multiple types of programmed cell death. Cu...
Below, we summarize the epigenetic modifications and PTMs regulating ferroptosis in CNS diseases (Table 8 and Fig. 7). Table 8 Epigenetic and posttranslational modification of Ferroptosis in neurological diseases Full size table Fig. 7 Epigenetic and posttranslational modification of ferroptosis in CNS...
(Supplementary information, TableS2) have been reported to regulate the process and function of ferroptotic cell death. Here, we will summarize the emerging regulatory network that affects ferroptosis, as well as its potential pathogenic role in diseases, while emphasizing unresolved questions in this...
Neurodegeneration encompasses a spectrum of diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and others, characterized by neuronal death and loss of neurological function [208]. Iron accumulation and lipid peroxidation are common pathophysiological features of these cond...
The aggregation of DNAJB6 protein is commonly found in neurological dis- eases such as Parkinson's disease and Huntington's dis- ease [94]. Yu et al. observed high expression of DNAJB6 in ovarian cancer tissues, and speculated that DNAJB6 could be a potential target for patient ...
Recent research indicates a strong connection between ferroptosis and a range of pathophysiological conditions, including tumors, neurological disorders, ischemia-reperfusion injuries, kidney damage, and hematological diseases. The regulation of ferroptosis to intervene in the progression o...
In essence, while p53 was initially identified in the context of cancer, its profound implications in neurological diseases, especially radiation-induced brain injuries, cannot be overlooked [68]. Its ability to modulate ferroptosis, primarily by influencing the expression of its target genes, offers ...
health and is closely linked with various metabolic, neurological, and immune-related disorders. Therefore, in addition to focusing on how to promote ferroptosis in cancer cells, there is also a need to focus on how to minimize the damage to normal cells and reduce the risk of potential side...