Additionally, GSEA revealed immune and tumor-related pathways in the low-risk group. TCGA showed that the p53 signaling pathway, ferroptosis, Kaposi sarcomaassociated herpesvirus infection, IL17 signaling pathway, MicroRNAs in cancer, TNF signaling pathway, PI3KAkt signaling pathway and HIF1 signaling ...
The workflow for identifying ferroptosis-associated genes and constructing signature is delineated in Fig.1a. We collected ferroptosis-related genes from ferroptosis database (FerroDb)14, while gene expression matrix and clinical traits of EGFRWTLUAD patients were extracted from The Cancer Genome Atlas ...
when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may
Recent bioinformatics analysis suggests that ferroptosis related genes might be associated with lung adenocarcinoma (LUAD). CPT1A and GDF15 are critical for the process of ferroptosis and development of inflammation; however, little study focused on the mutation level of these genes in patients with ...
In order to better understand the potential regulatory mechanism of ferroptosis in animal reproduction, we collated multiple ferroptosis-related genes, which are expressed in sperms, oocytes, follicles, embryos, the placenta, and/or the uterus, Furthermore, the prospective role of ferroptosis in ...
GSE89632, another microarray dataset, was used to validate the expression of ferroptosis-related genes. A protein–protein interaction (PPI) network of ferroptosis-related genes was then constructed. The target genes were also subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and ...
Quantitative real-time PCR (qRT-PCR) was used to validate the expression of ferroptosis-related genes in STAD cells lines. Results:A ceRNA network consisting of 29 DElncRNAs, 31 DEmiRNAs, and 182 DEmRNAs was constructed. These DEmRNAs were significantly enriched in pathways related to the ...
BMC Cardiovascular Disorders (2024) 24:531 https://doi.org/10.1186/s12872-024-04220-3 BMC Cardiovascular Disorders RESEARCH Open Access The role and possible mechanism of the ferroptosis-related SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury Bingxin Chen1,3, Ping Fan1, ...
In summary, eight new ferroptosis-related genes can be used to predict the prognosis of CRC. Gallic acid can improve CRC by regulating ferroptosis. 展开 关键词: Colorectal cancer Ferroptosis Gallic acid Natural product.DOI: 10.7150/ijbs.57164 年份: 2021 ...
regulation and ferroptosis in cardiovascular disease. Therefore, in this review, we provide an initial summary of the core mechanisms of ferroptosis in cardiomyocytes, with first focus on the epigenetic regulation and expression of ferroptosis-related factors in the context of common cardiovascular ...