The list of ferroptosis-related genes was extracted from the FerrDb website. Differentially expressed genes (DEGs) were identified by R "limma" package and used to screen ferroptosis-related hub genes. The random forest algorithm was used to construct the diagnostic model thro...
摘要: Ferroptosis-related genes GPX4 and TFRC were closely correlated with the identified overlapping genes CCNA2 and CDK1 , which may serve as targeted therapies for the treatment of CA.关键词: Coronary atherosclerosis Ferroptosis Overlapping genes Bioinformatics analysis ...
HOTAIR, a new type of lncRNAs belonging to a subclass of intergenic lncRNAs tightly regulates genes related to mammalian embryonic development [123]. HOTAIR expression is highly upregulated in BC, and silencing HOTAIR induces apoptosis and prevents cell proliferation. The mechanism of action involves...
GSE89632, another microarray dataset, was used to validate the expression of ferroptosis-related genes. A protein–protein interaction (PPI) network of ferroptosis-related genes was then constructed. The target genes were also subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and ...
genes: 35 upregulated and 31 downregulated genes (Fig.2B). Heat maps created using the R package pheatmap (Fig.2D) clearly indicate the 66 differentially expressed genes in various subgroups of the combined IS dataset. Box plots of expression levels revealed that all genes related to ferroptosis...
related genes were obtained from FerrDb, a web-based resource. FerrDb provides a comprehensive and up-to-date list of ferroptosis markers, regulatory molecules and ferroptosis-disease associations37. We obtained 259 (Driver: 108; suppressor: 69; marker: 111) ferroptosis-related genes. Pearson ...
Ferroptosis-related genes in neurodevelopment and central nervous system. Biology. 2021;10:35. Hassannia B, Vandenabeele P, Vanden Berghe T. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35:830–49. Article CAS PubMed Google Scholar Murphy MP. Metabolic control of ferroptosis ...
Using the Swiss Target Prediction database, 102 genes for potential drug target of juglone were selected. The intersection of the predicted drug targets and the ferroptosis-related genes from FerrDb database identified 27 key targets (Fig. 4A), which were analyzed using the String database and ...
To investigate the relationship between these three elements, we first obtained a list of Ferroptosis-related genes from the Ferrdb website and identified 14 IRGs that are associated with Ferroptosis (Fig.7A). Subsequently, we downloaded gene expression matrices and clinical files of 33 cancer types...
2 Expression of ferroptosis related genes. a. Expression of ferroptosis related genes in PMN from blood and tumour of cancer patients. qRT-PCR performed in CD11b+CD14−CD66b+ PMN isolated from blood (PB, n = 9) and tumours (Tumour, n = 6) of cancer patients. Ct value of ...