For nonneoplastic kidney diseases, renal function can be improved by the application of ferroptosis inhibitors, such as lipid peroxidation pathway inhibitors, iron homeostasis regulators, and ROS generation inhibitors. However, in renal cell carcinoma, ferroptosis inducers can be used to prevent the ...
Ferroptosis is a new form of non-apoptotic programmed cell death. Due to its effectiveness in cancer treatment, there are increasing studies on the application of nanoparticles based on ferroptosis in cancer therapy. In this paper, we present a summary of the latest progress in nanoparticles based...
Ferroptosis is an iron- and lipotoxicity-dependent form of regulated cell death (RCD). It is morphologically and biochemically distinct from characteristics of other cell death. This modality has been intensively investigated in recent years due to its involvement in a wide array of pathologies, inc...
A. Mey, a plant of the araliaceae family, which is recorded in the Chinese Pharmacopoeia and has been widely used for diseases treatment in China for thousands of years [18]. Ginsenosides, the main bioactive natural compounds of ginseng, have been shown to have a wide range of ...
Research progress of ferroptosis in cardiovascular diseases. Chinese Journal of Thoracic and Cardiovascular Surgery, 2022, 29(4): 497-501. doi: 10.7507/1007-4848.202102029 孔朋旭, 潘湘斌. 水凝胶植入在心力衰竭治疗中的研究进展. 中国胸心血管外科临床杂志, 2022, 29(4): 502-507. doi: 10.7507/1007-...
process and might provide novel therapeutic targets for relevant diseases. In this review, we first summarized the biological mechanisms of ferroptosis in detail and introduced some key molecules and redox systems that are related to ferroptosis. Next, we described the signal transduction pathways ...
2. Inflammatory pathogenesis of DN 3. TLR4 introduction 4. Natural compounds improve DN by regulating the TLR4 signaling pathway 5. Role of molecular structures in the regulation of the TLR4 signaling pathway 6. Conclusion and future perspectives CRediT author statement Declaration of competing interest...
SHI Huanxu, HE Peiyu, TONG Qi,et al. Prediction and risk factors of recurrence of atrial fibrillation in patients with valvular diseases after radiofrequency ablation based on machine learning. Chinese Journal of Thoracic and Cardiovascular Surgery, 2022, 29(7): 840-847. doi: 10.7507/1007-4848...
cancer, novel ferroptosis agonists have shown promise in several cancer types. On the other hand, antagonists of ferroptosis have been shown to help alleviate ferroptosis-related diseases such as ischemia/reperfusion (I/R)-induced damage, neurodegenerative diseases, and inflammatory diseases.3,4,5,6...
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune sy...