For nonneoplastic kidney diseases, renal function can be improved by the application of ferroptosis inhibitors, such as lipid peroxidation pathway inhibitors, iron homeostasis regulators, and ROS generation inhibitors. However, in renal cell carcinoma, ferroptosis inducers can be used to prevent the ...
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene ex...
Ferroptosis has been proved to be closely linked to a variety of diseases, especially cancer. This review aims to summarize the core mechanism of ferroptosis in esophageal cancer, the regulation of ferroptosis signaling pathway and its current application. At the same time, we emphasize the ...
Ferroptosis is an iron- and lipotoxicity-dependent form of regulated cell death (RCD). It is morphologically and biochemically distinct from characteristics of other cell death. This modality has been intensively investigated in recent years due to its involvement in a wide array of pathologies, inc...
process and might provide novel therapeutic targets for relevant diseases. In this review, we first summarized the biological mechanisms of ferroptosis in detail and introduced some key molecules and redox systems that are related to ferroptosis. Next, we described the signal transduction pathways ...
Chinese Medicine in the Treatment of Ulcerative Colitis: The Mechanisms of Signaling Pathway Regulations Shihao Zheng, Tianyu Xue, Bin Wang, Haolin Guo, and Qiquan Liu Vol. 50, No. 07 Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway ...
Alcoholic liver disease (ALD) is one of the most common chronic liver diseases in the world caused by long-term excessive alcohol consumption [1]. It can progress and lead to liver fibrosis, cirrhosis, and even liver cancer, which seriously endangers people's health [2,3,4]. The pathogenes...
Research progress of ferroptosis in cardiovascular diseases. Chinese Journal of Thoracic and Cardiovascular Surgery, 2022, 29(4): 497-501. doi: 10.7507/1007-4848.202102029 孔朋旭, 潘湘斌. 水凝胶植入在心力衰竭治疗中的研究进展. 中国胸心血管外科临床杂志, 2022, 29(4): 502-507. doi: 10.7507/1007-...
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and associated with a plethora of pathological conditions in the liver. Emerging evidence supports the notion that dysregulated metabolic path
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metab