It has garnered attention due to the growing body of evidence linking ferroptosis and fibrogenesis, which is believed to be driven by underlying inflammation and immune responses. Despite the increasing interest in the relationship between ferroptosis and fibrosis, a comprehensive understanding of the ...
Ferroptosis is an iron- and lipotoxicity-dependent form of regulated cell death (RCD). It is morphologically and biochemically distinct from characteristics of other cell death. This modality has been intensively investigated in recent years due to its involvement in a wide array of pathologies, inc...
have been implicated in the pathogenesis of various liver diseases. With respect to liver injury, steatohepatitis, fibrosis, and cirrhosis, liver cells are more susceptible to ferroptosis; in contrast, in liver cancer the cancer cells are either intrinsically resistant to ferroptosis or acquire resistan...
important role in renal fibrosis, which is the most pivotal pathological change in CKD. Studies have indicated targeting ferroptosis with specific drugs promotes adaptive cell repair and ameliorates fibrosis, suggesting drug intervention in ferroptosis as a potential avenue for preventing kidney fibrosis [...
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell death that differs from apoptosis, autophagy, and pyrodeath. This distinct pattern
Ferroptosis is a cell death pathway that has been the focus of increasing investigation due to its theorized role in numerous human diseases. Ferroptosis lacks typical apoptotic features such as chromatin condensation and apoptotic body formation, as well as the formation of autophagosomes, a character...
Overview of ferroptosis Cell death is a crucial aspect of healthy biological development; however, abnormal cell death is implicated in a wide range of diseases [15]. For a long time, cell death was considered uncontrolled; however, in the 1950s, the concept of “programmed cell death” was...
Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states. This condition can lead to significant he
Breast cancer (BC) affects the breast tissue and is the second most common cause of mortalities among women. Ferroptosis is an iron-dependent cell death mode that is characterized by intracellular accumulation of reactive oxygen species (ROS). We constru
Ferroptosis is a cell death pathway that has been the focus of increasing investigation due to its theorized role in numerous human diseases. Ferroptosis lacks typical apoptotic features such as chromatin condensation and apoptotic body formation, as well as the formation of autophagosomes, a character...