7. Li JM, Shen X, Hu PP, Wang XF. Transforminggrowth factor beta stimulates the human immunodeficiency virus 1 enhancer andrequires NF-kappaB activity. Mol. Cell Biol. 1998 Jan; 18(1): 110-21. PubMedID: 9418859
TβRIII又名Endoglin或CD105,是一种蛋白聚糖,虽然也是跨膜蛋白,但其胞内段缺乏激酶活性,不直接参与信号转导,主要是调节TGFβ同信号受体的结合。它与TGF-β1、TGF-β2、TGF-β3的亲和力近似,TGF-β1和TGF-β3为其主要配体。 2、TGFβ信号转导 TβRI和TβRII复合物完整性是TGFβ信号转导所必需的。I型受...
TGF-beta is known to inhibit many of the immune cell functions including T cell proliferation and IL-2 production. The mechanism of such TGF-beta-mediated inhibition of T cell functions is poorly understood. The present study examined the effects of TGF-beta on the activation of protein ...
- 《Cell Growth & Differentiation the Molecular Biology Journal of the American Association for Cancer Research》 被引量: 0发表: 1999年 IL-33通过ST2/ERK1/2/MSK1信号通路促进哮喘气道重塑机制的研究 背景: 支气管哮喘(简称哮喘)是由嗜酸性粒细胞,中性粒细胞,T淋巴细胞,肥大细胞等炎症细胞和气道上皮细胞...
11. Massagué J. TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med. 2000; 342(2):69-77.13. Papageorgis P, Stylianopoulos T. Role of ...
作用于TGF.p受体I的干扰RNA通过阻断TGF.p信号通路降低T24细 胞的侵袭、迁移能力,同时降低整合素蛋白和MMP9蛋白的表达,由此证明膀胱 癌中过表达的TGF一131、TGF-p受体特异性干扰RNA可能通过调节整合素蛋白和 IV 浙江人学硕Ij学位论义 中文摘要 MMP9蛋白的表达而影响T24细胞的侵袭、迁移能力,所以应用TsiRNA阻断TGF一...
重组人转化生长因子-β2蛋白产品,又称Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin.其对应NCBI基因号为7040,NCBI基因别称为TGFB1;该基因种属来源为人源,对应Accession号为P01137.该蛋白产品又称Human TGF-beta2, TGF-beta2, h-TGF-beta2, rh-...
TGF-beta-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol. 2016;196:3631-41.TGF-β-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. ... A Xu,Y Liu,W Chen,... - 《Journal of Immunology》...
Current excitement focuses on active suppression and new regulatory T cell-mediated pathways of immunosuppression that are being unraveled. Central to several of these pathways is transforming growth factor-beta (TGF-beta), a potent immunoregulatory cytokine that contributes to the function and generation...
TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth,and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.应用类型 Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be ...