Thus, our findings not only identify a possible mechanism by which breast cancer cells can promote T cell exhaustion and dampen host anti-tumor immunity, but may also identify a target for immune therapy against the most devastating breast tumors....
TGF-β signaling can inhibit cell growth in benign cells but promote cancerous biological behaviors in cancer cells; this phenomenon is known as the TGF-β paradox [8]. Paradoxical TGF-β functions are cell- and context-dependent with a specific molecular mechanism [9,10]. In benign cells, ...
Regarding the canonical TGFβ pathway, active TGFβ initially binds to the low-affinity accessory TGFβ type III receptor (TβRIII), also named betaglycan, which is abundant on the surface of many cell types (Fig.3a). Betaglycan can present TGFβ to the TGFβ receptor complex, which is ...
Persistent antigen exposure (e.g., tumor antigen) induces T cell exhaustion with reduced effector function1. Exhausted CD8+T cells are heterogenous and a less exhausted subset carries stem cell-like features2,3,4,5,6. These stem-like CD8+T cells express transcription factor Tcf-1 (T cell f...
For instance, TGF-β suppresses the activity of natural killer cells and enhances the population of regulatory T cells [32, 33]. TGF-β also enhances the process of antigen-specific T-cell exhaustion by increasing the expression of PD-1 [34]. In consistent with this, combinational usage of...
Dominant-negative TGF-beta receptor enhances PSMA-targeted human CAR T cell proliferation and augments prostate cancer eradication. Mol Ther. 2018;26(7):1855–66. Article CAS PubMed PubMed Central Google Scholar Narayan V, Barber-Rotenberg JS, Jung IY, Lacey SF, Rech AJ, Davis MM, et al...
transforming growth factor-beta 1 (TGF-b1) upregulated SOX18 expression by activating the Smad2/3 complex.”(Chen 等, 2024, p. 264) SOX18 过表达促进肿瘤相关巨噬细胞 (TAM) 和调节性 T 细胞 (Treg) 的浸润,同时减少细胞毒性 T 细胞,从而促进细胞来源的同种异体移植物和化学诱导的 HCC 模型中的...
Expression of the dnTGF-βRII in CAR T cells increased lymphocyte proliferation, enhanced cytokine secretion, promoted T cell resistance to exhaustion and increased tumor eradication in aggressive human prostate cancer models. TGF-β pathway biomarkers to predict cancer risk and therapeutic response ...
目的探讨特发性血小板减少性紫癜(ITP)患儿骨髓血小板生成素(TPO),血小板反应素1(TSP1)和转化生长因子β1,(TGFβ1)水平变化的意义.方法收集22例ITP患儿及17例相对正常儿童骨髓;ELISA法检测骨髓上清液TPO,TSP1和TGFβ1的含量.结果ITP患儿骨髓TSP1和TGFβ1水平均明显高于对照组(P0.05);TPO水平稍高于对照组,但差异...
(CAFs) and enhanced tissue remodeling, recruitment of immunosuppressive cells, induction of immune checkpoints (e.g., PD-L1), and, consequently, T cell exhaustion and tumor immune tolerance (Abdollahi and Folkman, 2010; Barker et al., 2015; Twyman-Saint Victor et al., 2015; Vanpouille-Box...