pancreatic cancerreceptorSmadgrowth arrest and DNA damage-45βp38 mitogen-activated protein kinaseRac1NADPH oxidaseprotein kinase Ctransforming growth factor-βThe small leucine-rich proteoglycan (SLRP) biglycan is a major constituent of many extracellular matrices and is overexpressed in stroma-rich ...
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Pancreatic cancer is highly lethal malignant tumor with characterised rapid progression, invasiveness and resistance to radiochemotherapy. Transforming growth factor-β (TGF-β) signaling plays a dual role in both pro-tumorigenic and tumor suppressive of pancreatic cancer, depending on tumor stage and mi...
National Cancer Institute pancreatic cancer Glossary Loss of heterozygosity Tumour cells often lose large genomic regions at loci that often contain tumour-suppressor genes. In cells that carry a mutated allele of a tumour-suppressor gene, the loss of a large region from a chromosome that carries...
TGF-β signaling in pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal cancer, with 5 year survival rates of 2–9%, and no effective treatments currently [85]. As the case in general for TGF-β signaling, it plays a complex dual role [86]. In pre-cancerou...
Pancreatic stellate cells (PSCs) secrete high levels of transforming growth factor-β1 (TGF-β1) that contributes to the development of pancreatic ductal adenocarcinoma (PDAC). TGF-β1 modulates the expression of L1 cell adhesion molecule (L1CAM), but it
Loss of Type Iii Transforming Growth Factor Beta Receptor Expression Increases Motility and Invasiveness Associated with Epithelial to Mesenchymal Transition During Pancreatic Cancer Progression[J]. Carcinogenesis,2008,29(2):252-262. [25] Han G,Lu SL,Li AG,et al. Distinct Mechanisms of Tgf-beta(1...
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