Transforming growth factor beta ( TGF尾) has long been implicated in fibrotic disorders and is commonly defined as the 'master switch' of fibrosis. However the actions governed by TGF尾 can be complex and diverse involving multiple signalling pathways and cross-talk between many signalling cascades...
纤维化(Fibrosis)是一种累及多个器官、不可逆转的病理过程,它的形成是指胶原蛋白(collagen)、纤维粘连蛋白(fibronectin, FN)、α-平滑肌肌动蛋白(alpha-smooth muscle actin, α-SMA)等细胞外基质(extracellular matrix, ECM)过度堆积,成纤维细胞向肌成纤维细胞分化,实际上这是器官组织修复的一个重要阶段。但是当组织...
1.Massagué J. TGFbeta in Cancer.Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. PMID:18662538; PMCID: PMC3512574. 2.Vander Ark A, et al. TGF-βreceptors: In and beyond TGF-β signaling. Cell Signal. 2018 Dec;52:112-120.doi: 10.1016/j.cellsig.2018.09.002....
1.Massagué J. TGFbeta in Cancer.Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. PMID:18662538; PMCID: PMC3512574. 2.Vander Ark A, et al. TGF-βreceptors: In and beyond TGF-β signaling. Cell Signal. 2018 Dec;52:112-120.doi: 10.1016/j.cellsig.2018.09.002....
TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis. BACKGROUND: Polymorphisms in transforming growth factor (TGF)-beta(1) associated with variations in cytokine levels are linked to fibrosis in a number of t... Arkwright,P. D - 《Thorax》 被引量:...
TGF-beta Fibrosis Pathway Antibody Sampler Kit 价 格 电议 起批量 ≥1 Kit 最小起订电询 供货总量电询 发货地址上海市浦东新区 建议售价￥电议/Kit 更新日期 2025年04月14日 产品规格见优宁维官网 即时洽谈 立即询价 查看联系方式 收藏产品 发送留言 举报 VIP4年 上海优宁维生物科技股份有限公司 ...
TGF-β受体（TGF-β receptors，TβR）广泛存在于正常细胞及肿瘤细胞表面，包括I型（TβRI）、II型（TβRII）、III型TβRIII（betaglycan）及endoglin等。目前研究较多的是I型和II型两种受体，参与多种信号的转导。迄今为止，已鉴定出七种I型TGF-β受体（TβRI），分别命名为活化素受体样激酶1-7 (activin ...
Goumans, M. J. & Mummery, C. Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.Int. J. Dev. Biol.44, 253–265 (2000). CASPubMedGoogle Scholar Inazaki, K.et al. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral...
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice. Int. J. Dev. Biol. 44, 253–265 (2000). CAS PubMed Google Scholar Inazaki, K. et al. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. ...
Autocrine TGF-β Signaling by Tubules Causes Fibrosis in the Injured Kidney A Winding Road from GPCRs to TGF-β Activation and Profibrogenic Peptide Secretion by Tubular Cells LPA Is One of the Several Possible Ligands to Activate the GPCR–αvβ6 Integrin–TGF-β Axis The Case for Integrin-...