Liver fibrosis is the final consequence of many chronic liver injuries that later develop in cirrhosis and hepatocellular carcinoma (HCC), which are leading causes of morbidity and mortality worldwide. The transforming growth factor-beta (TGF-β) represents a key cytokine that increases in liver in...
纤维化(Fibrosis)是一种累及多个器官、不可逆转的病理过程,它的形成是指胶原蛋白(collagen)、纤维粘连蛋白(fibronectin, FN)、α-平滑肌肌动蛋白(alpha-smooth muscle actin, α-SMA)等细胞外基质(extracellular matrix, ECM)过度堆积,成纤维细胞向肌成纤维细胞分化,实际上这是器官组织修复的一个重要阶段。但是当组织...
J. MicroRNAs, transforming growth factor beta-1, and tissue fibrosis. J. Pathol. 229, 274–285 (2013). CAS PubMed Google Scholar Qin, W. et al. TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J. Am. Soc. Nephrol. 22, 1462–1474 (2011). CAS PubMed PubMed ...
Objective To study the relationship between the platelet derived growth factor-BB (PDGF-BB), transforming growth factor beta 1 (TGF beta 1) and hepatic fibrosis and PDGF-BB, TGF beta 1in liver fibrosis diagnosis value. Methods The serum level of PDGF-BB and TGF beta 1 were analyzed in 123...
Due to the ability to control the level of TGF-beta1 expression, this model allows the study of the regulation and kinetics of collagen synthesis and fibrolysis as well as the degree of reversibility of liver fibrosis. The CRP/TGF-beta1 transgenic mouse model may finally serve as a model ...
anti-transforming growth factor-beta, and an transforming growth factor-beta 1 antibodies in dermal fibroblasts : implications for wound healing.Wound Repair Regen, 2004, 12:53-59. [18] Arthur MJ.Fibrogenesis-II, metalloproteinases and their inhibitors in liver fibrosis . Am J Physiol Gast...
Goumans, M. J. & Mummery, C. Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.Int. J. Dev. Biol.44, 253–265 (2000). CASPubMedGoogle Scholar Inazaki, K.et al. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral...
Long noncoding RNAs (lncRNAs) play important roles in various biological processes such as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA, named liver fibrosis-associated lncRNA1 (lnc-LFAR1), promotes liver fibr
TGF-beta1 gene silencing for treating liver fibrosis. Small interfering RNA (siRNA) and short hairpin RNA (shRNA) targeting different regions of transforming growth factor beta1 (TGF-beta1) mRNA were designed ... K Cheng,N Yang,RI Mahato - 《Mol Pharm》 被引量: 242发表: 2009年 Loss of...
The role of the miR-31/FIH1 pathway in TGF-beta-induced liver fibrosis The miRNAs are small, non-coding RNAs that regulate various biological processes, including liver fibrosis. Hepatic stellate cells (HSCs) play a central ro... Hu, JiangfengChen, ChaoLiu, QidongLiu, BaohaiSong, Chenlin...