Tfh cell differentiation and their function in promoting B-cell responses. Adv Exp Med Biol. 2014;841:153-180.H. Qi, X. Chen, C. Chu, D. Liu, W. Ma, Y. Wang, L. Wu, H. Yan, J. Yan, Tfh cell differen- tiation and their function in promoting B-cell responses, Adv. Exp. ...
Objectives To investigate the frequencies of Tfh cells and B cell profiles in DM patients. To further determine the association of Tfh cells and B cells in DM patients and clarify the possible mechanism. Methods Peripheral blood mononuclear cells (PBMCs) were isolated from DM patients and age, ...
This correlated with the shift in dLN T follicular regulatory (Tfr)/T follicular helper (Tfh) cell ratio towards Tfh cells in females, and greater densities of CD40L and CD40 on their dLN T and B cells, respectively. The higher Tfh cell frequency in females was consistent with the greater ...
The ability of B cells to undergo selection and differentiation into long-lived plasma cells and memory B cells is dependent on signals from T follicular helper (Tfh) cells within GCs [2,3] (Figure 1). Tfh cells are a distinct T cell subset that can be distinguished from other CD4+ T ...
We identify the interfollicular (IF) zone of the lymph node as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first two days post-immunization, antigen-specific T and B cells remained confined within the IF zone, where they participa...
Antibody production and B-cell phenotype in NB patients. a Total serum level of IgG, IgA and IgM were measured by ELISA in NB patients (n = 43) and health controls (n = 52). Each dot represents one individual. *P < 0.05, ns = not significantly different. b The pe...
Recently, T follicular helper (TFH) cells have been clearly described as a specialized subset of [CD4.sup.+] T cells, which distinguish from Th1, Th2, Th17, and Treg and localize to B cell follicles of germinal center (GC), where they can regulate the humoral immune responses [10-14]...
Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (TFH) cells. However, the longevity and functional role of TFHcell subsets in COVID-19 convalescent...
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Tfh cells induce B cells differentiation and promote immunoglobulin secretion by IL-21 secretion. During SSc, cTfh cells impairment is associated with an imbalance of B cell subsets [25,35]. Frequencies of both naïve B cells and plasmablasts are increased while the frequency of memory B cells...