CD4T cells mediate rheumatoid arthritis (RA) pathogenesis through both antibody-dependent and independent mechanisms. It remains unclear how synovial microenvironment impinges on CD4T cells pathogenic functions. Here, we identified a TLR4follicular helper T (Tfh) cell-like population present in the ...
and support B cells. In addition, these CXCR3+PD-1loTfh-like cells contained higher proportions of stem cell–like memory T cells, and upon antigenic stimulation differentiated into PD-1hiTfh-like cells in a Notch-dependent manner. Together, these data suggest that ...
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with fe...
Induction of long-lived antibody responses during infection or vaccination is often essential for subsequent protection, but the relative contributions of T follicular helper (Tfh) cells and T helper 1 (Th1) cells for induction of antigen specific a
Tfh-like cells express MyoR mRNA.Delphine DebuissonNathalie MariSébastien DenanglaireOberdan LeoFabienne Andris
Tfh-like cellsTransfusion medicineBACKGROUND :People living with sickle cell disease (SCD) are prone to red blood cell (RBC) alloimmunization. We hypothesized that subjects with alloantibodies (responders) would have differences in circulating T-follicular helper (Tfh)-like cells compared to subjects...
Mapping the immune terrain in lung adenocarcinoma progression: Tfh-like cells in tertiary lymphoid structuresdoi:10.1007/s13402-024-00936-8Jialei Gonghttps://ror.org/00rqy9422grid.1003.20000 0000 9320 7537Frazer Institute, Faculty of MedicineThe University of Queensland 4102 Brisbane Queensland Australia...
CD4+Foxp3-PD-1hi T cells (4PD1hi) that increase in tumor-bearing hosts after immune checkpoint blockade (ICB) constitute an unconventional T-cell inhibitory subset with TFH-like features, which can affect the outcome of cancer immunotherapy. Inhibition of the molecular pathway leading to the ...
Conclusions Tfh-like cells are significantly more represented in ELS-positive than in ELS-negative synovium. IL-21-producing CD4+ T cells in synovial fluid might have a direct pro-inflammatory effect on FLS via IL-21/IL-21R signalling.
However, an increased CXCR3 expression was observed on total CD4T and Tfh-like cells from lupus skin lesions. Moreover, we observed higher expression level of CXCR3 in Tfh cells from human tonsils. These findings indicate that CXCR3 might help Tfh-like cells to migrate into the inflammatory ...