2022年2月21日,美国哈肯萨克大学医学中心(Hackensack University Medical Center)薛海晖教授团队和弗吉尼亚大学(University of Virginia)臧充之教授团队合作在Nature Immunology上发表了题为Tcf1 preprograms the mobilization of glycolysis in central memory CD8+T cells during recall responses的研究论文,揭示了转录因子Tcf...
近期多项报道指出,免疫检查点抑制治疗可以促进前体细胞的分化,也可以这样理解,也就是前体细胞的水平与免疫检查点抑制治疗的疗效息息相关。前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签相符合。 因为SIIN诱导CD8+T细胞水平比SIY更高,作者猜测这一竞争结果很可能...
BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen. Immunity. 2022 May 25:S1074-7613(22)00223-0. doi: 10.1016/j.immuni.2022.05.003. Epub ahead of print. PM...
1. Hosokawa, H. & Rothenberg, E. V. How transcription factors drive choice of the T cell fate.Nat Rev Immunol21, 1–15 (2020). 2. Hu, G.et al.Transformation of Accessible Chromatin and 3D Nucleome Underlies ...
美国哈肯萨克大学医学中心 (Hackensack University Medical Center) 薛海晖教授团队和弗吉尼亚大学 (University of Virginia) 臧充之教授团队合作在《自然—免疫学》(Nature Immunology)上发表了题为“Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses”的研究论文,...
In this short review, we summarized recent progress in intratumoral exhausted CD8+ T cells expressing TCFthat represent a fantastic subset with stem cell﹍ike properties that associated with improved antitumor immunity and response to immune checkpoint blockade (ICB). Summarizes recent studies showing ...
5. Srenathan, U., Steel, K., and Taams, L.S. (2016). IL-17+ CD8+ T cells: Differ- entiation, phenotype and role in inflammatory disease.Immunol. Lett.178, 20–26. 注:本文来自BioArt微信公众号,更多生物领域前沿信息等你来发现!
Recent advances bring TCF1 into the spotlight for its versatile, context-dependent functions in regulating mature T cell responses. In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8+ T cells generated in response to viral or tumour antigens, and for ...
调节T细胞(regulatory T cells, Treg)是CD4 T细胞中一个特殊的亚群,其特异性的表达转录因子FOXP3。调节T 细胞的一个主要功能在于抑制来自其他免疫细胞过度的免疫反应【1】。近年来,越来越多的证据表明Treg是一个包括多个亚群的细胞类型,每个亚群都具有不同的转录因子表达,使得其获得类似于其他 CD4 T细胞亚群的特性,...
TCF7基因特异性敲除的一种T细胞。Tcf7叫做Transcription factor 7，也叫T-Cell-Factor-7，似乎与T细胞激活有关。-/-代表纯合子，说明这个基因是完全缺失的。-/+代表部分缺失，有部分细胞还是会表达。P14是改造的可以特异性识别gp33的一种T细胞，gp33-specific TCR transgenic T cells。GP33：糖蛋白...