2022年2月21日,美国哈肯萨克大学医学中心(Hackensack University Medical Center)薛海晖教授团队和弗吉尼亚大学(University of Virginia)臧充之教授团队合作在Nature Immunology上发表了题为Tcf1 preprograms the mobilization of glycolysis in central memory CD8+T cells during recall responses的研究论文,揭示了转录因子Tcf...
BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen. Immunity. 2022 May 25:S1074-7613(22)00223-0. doi: 10.1016/j.immuni.2022.05.003. Epub ahead of print. PM...
3. Silva, J.G., Pais Ferreira, D., Dumez, A., Wyss, T., Veber, R., Danilo, M., Pinschewer, D.D., Charmoy, M., and Held, W. (2023). Emergence and fate of stem cell–like Tcf7+ CD8+ T cells dur...
Recent advances bring TCF1 into the spotlight for its versatile, context-dependent functions in regulating mature T cell responses. In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8+ T cells generated in response to viral or tumour antigens, and for ...
In this short review, we summarized recent progress in intratumoral exhausted CD8+ T cells expressing TCFthat represent a fantastic subset with stem cell﹍ike properties that associated with improved antitumor immunity and response to immune checkpoint blockade (ICB). Summarizes recent studies showing ...
调节T细胞(regulatory T cells, Treg)是CD4 T细胞中一个特殊的亚群,其特异性的表达转录因子FOXP3。调节T 细胞的一个主要功能在于抑制来自其他免疫细胞过度的免疫反应【1】。近年来,越来越多的证据表明Treg是一个包括多个亚群的细胞类型,每个亚群都具有不同的转录因子表达,使得其获得类似于其他 CD4 T细胞亚群的特性,...
5. Srenathan, U., Steel, K., and Taams, L.S. (2016). IL-17+ CD8+ T cells: Differ- entiation, phenotype and role in inflammatory disease.Immunol. Lett.178, 20–26. 转载须知 【原创文章】BioArt原创文章,欢迎个人转发分享,未经允许禁止转载,所刊登的所有作品的著作权均为BioArt所拥有。BioArt...
美国哈肯萨克大学医学中心 (Hackensack University Medical Center) 薛海晖教授团队和弗吉尼亚大学 (University of Virginia) 臧充之教授团队合作在《自然—免疫学》(Nature Immunology)上发表了题为“Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses”的研究论文,...
Title: Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade Pubication Data: 2016/10/27 Journal: Science 一直以来,我们认为PD-1治疗可以逆转肿瘤免疫抑制微环境,从而使得瘤内的肿瘤反应性T细胞可以恢复功能,清除肿瘤。然而,本文研究发现: PD-1治疗后并不能有效逆转T细...
TCF7基因特异性敲除的一种T细胞。Tcf7叫做Transcription factor 7，也叫T-Cell-Factor-7，似乎与T细胞激活有关。-/-代表纯合子，说明这个基因是完全缺失的。-/+代表部分缺失，有部分细胞还是会表达。P14是改造的可以特异性识别gp33的一种T细胞，gp33-specific TCR transgenic T cells。GP33：糖蛋白...