2023年8月17日,来自美国宾夕法尼亚大学的Golnaz Vahedi研究团队在Nature Immunology上发表题为Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity的文章,发现敲除先锋转录因子TCF-1的内...
T cell factor 1 (TCF-1) is a critical regulator of intraepithelial lymphocytes in colorectal carcinoma
今年8月在本刊发表了题为Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single-cell resolution的研究论文。本研究通过多种基因敲除小鼠模型结合单细胞测序分析,对Tcf-1在早期T细胞发育和T细胞...
最近的研究强调了T-IELs在肠道和全身性疾病的作用，如肠炎 (Nature | γδ上皮内淋巴细胞效应蛋白API5影响克罗恩病遗传易感性；Science丨共生菌抗原通过诱导肠道T淋巴细胞分化来缓解肠炎)，肠癌【1】，糖尿病和动脉粥样硬化（Nature丨心血管疾病与肠道免疫细胞代谢活动密切相关；Cell Metab | 胰高血糖素样肽1（GLP-...
近期多项报道指出,免疫检查点抑制治疗可以促进前体细胞的分化,也可以这样理解,也就是前体细胞的水平与免疫检查点抑制治疗的疗效息息相关。前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签相符合。 因为SIIN诱导CD8+T细胞水平比SIY更高,作者猜测这一竞争结果很...
progenitor exhausted T cellstemnessT cell factor 1 (TCF-1)T cell factor 1 (TCF is a transcription factor (TF) of the canonical Wnt signaling pathway that encoded by the Tcf7. The crucial role of TCFin T cell development and memory formation has been widely recognized. Recent studies have...
近日，来自哈佛医学院的Ana C. Anderson团队在Cancer Cell杂志上发表了一篇题为 Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy 的文章，他们发现CD8+T细胞中TCF1的表达对于低免疫原性肿瘤ICB反应而言是必需的，对于高免疫原性肿瘤的T细胞启动和治疗反应则是可有可无的...
2021年6月14日，美国哈肯萨克大学薛海晖团队（中国医科大学为第一单位，赵旭东为第一作者）在（IF=40.36）在线发表题为“TCF1 in T cell immunity: a broadened frontier”的综述文章，该综述总结了 TCF1 在 T 细胞免疫领域的主要发现，并反思了探索 TCF1 及其下游转录程序作为改善抗病毒和抗肿瘤免疫的治疗靶点...
The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has been classically viewed as a downstream effector of canonical Wnt
The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell development. Although in vitro biochemical assays suggest that HMG proteins can serve as architectural elements in the assembly of higher-order nuclear organization, t