今年8月在本刊发表了题为Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single-cell resolution的研究论文。本研究通过多种基因敲除小鼠模型结合单细胞测序分析,对Tcf-1在早期T细胞发育和T细胞...
The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has been classically viewed as a downstream effector of canonical Wnt signaling, although there is strong eviden...
Specifically, loss-of-function analysis revealed that only EPE3 plays a critical role in supporting αβ T cell development, while EPE1, 3, and 5 regulate the γδ T cell maturation and functional cell fate decision. The importance of EPE3 in supporting both lineages may stem from its ...
Nature immunology, 19(12), 1289-1299. [3] Yu, Q., et al. (2012). The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity, 37(5), 813-826.©2022 Baidu |由 百度智能云 提供计算服务 | 使用百度前必读 | 文库协议 ...
The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell development. Although in vitro biochemical assays suggest that HMG proteins can serve as architectural elements in the assembly of higher-order nuclear organization, t
前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签相符合。 因为SIIN诱导CD8+T细胞水平比SIY更高,作者猜测这一竞争结果很可能与SIY所诱导的TCF+前体细胞相关。为了证实这一猜测,作者分别构建了单独表达SIY和SIIN的小鼠(LucSIIN 和LucSIY ),并发现,仅SIY并不能...
Deletion ofTCF1 causes massive apoptosis of double positive thymocyte, suggesting that TCF1 isrequired for thymocyte survival during T cell development. In addition to its function in thymus,TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptionalactivation of GATA3....
在T细胞中, β-catenin 有一个重要的DNA结合共因子,T细胞转录因子1(transcription factor T cell factor 1, TCF-1)【6】。之前有研究表明TCF-1的缺失会导致胸腺调节T细胞的增加【7】,因此,TCF-1在调节T细胞中可能具有重要的功能。...
TCF1/TCF7 displays dynamic expression both in the total amount and the type of isoforms expressed in T cells during development and differentiation (7). Waterman, M.L. (2004) Cancer Metastasis Rev 23, 41-52. Schilham, M.W. and Clevers, H. (1998) Semin Immu...
TCF1/TCF7 displays dynamic expression both in the total amount and the type of isoforms expressed in T cells during development and differentiation (7). Waterman, M.L. (2004) Cancer Metastasis Rev 23, 41-52. Schilham, M.W. and Clevers, H. (1998) Semin Immunol 10, 127-32. Brantjes...