Tfh cells have been implicated in the development and progression of RA, and further research is needed to fully understand their role. The authors suggest that targeting Tfh cells could lead to new therapies for RA.doi:10.1007/s10067-024-07006-2Chen, Guanru...
Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucin...
32 Whether targeting cells in the local gut immune system could affect systemic vaccine responses is not known. By exposing mice to certain commensals, cells in the siLP can be skewed; segmented filamentous bacteria contributes to local Th17 induction,45 while Helicobacter hepaticus elicits RORγt+...
received the numerical designation from IL-9), TFH cells, type 2 innate lymphoid cells, mast cells, invariant NKT cells, mucosal-associated invariant T cells, NK cells, macrophages, basophils, eosinophils, IL-9–producing CD8 cytotoxic T (Tc9) cells, and Th2 and Th17 cells (1, 2, 4, ...
The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns over the course. Here, we
B. et al. VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells. Antioxid Redox Signal. 19, 448–464 (2013). 24. Murohara, T. et al. ...
Some proteins, such as programmed cell death protein 1 (PD1), can stop the immune system from attacking cancer cells, allowing cancers to grow. Therapies targeting these proteins can be highly effective, but tumors can become resistant. It is important to identify factors involved in this resista...
Additionally, both the mRNA and protein expression of the YAP target genes (BIRC5, SPP1, and MYC) were increased by the ALKBH5 overexpression in the cultured L02 cells (Figure 3A,B). Addition- Int. J. Mol. Sci. 2024, 25, 11537 5 of 17 ally, we examined the expression levels of ...
MAF has a well-established role in adaptive immunity, where it promotes the differentiation and function of Th2, Tr1, and TFH cells, as well as the expression of type 2 and suppressive cytokines (Apetoh et al., 2010, Liu et al., 2013, Pot et al., 2011) (Cao et al., 2005, Liu...
tteeiannsdcaanlmboesetxpprroetsesined-fruenedmeredthiuemm;eetlhimaninola-tiinodnuocfendePgaAtOiXv1e; ability effects of endotoxin and bacteriophage; diverse posttranslational modifications like polypeptide folding, glycosylation, methylation, acylation, proteolytic adjustment, and targeting to subcellular ...