The decrease of CXCR5(+) cells in circulation was also related to homing of B and T cells to the autoimmune target organ. Therapeutic drugs targeting ... Aqrawi, L. A.Ivanchenko, M.Bjork, A.Sepulveda, J. I. RamirezImgenberg-Kreuz, J.Kvarnstrom, M.Haselmayer, P.Jensen, J. L.Nord...
The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns over the course. Here, we
As MetaTiME MeCs provides a highly interpretable basis for the TME in single cells, we provided a toolkit to discover MeC signature continuums and enriched cell states in scRNA-seq TME data (code deposited inhttps://github.com/yi-zhang/MetaTiME). The MetaTiME annotation toolkit takes as input...
We synchronized HeLa cells at the boundary of the G1–S transition using a double thymidine block to evaluate the changes in the expression of MED28 during the cell cycle. After the release of the cells from the G1–S transition block, the cells were harvested at various time points, as...
MAF has a well-established role in adaptive immunity, where it promotes the differentiation and function of Th2, Tr1, and TFH cells, as well as the expression of type 2 and suppressive cytokines (Apetoh et al., 2010, Liu et al., 2013, Pot et al., 2011) (Cao et al., 2005, Liu...
microenvironment imprint (overexpression of B-cell– and follicular dendritic cell–related genes, chemokines, and genes related to extracellular matrix and vascular biology), and overexpression of several genes characteristic of normal follicular helper T (TFH) cells (CXCL13, BCL6, PDCD1, CD40L, ...
Differential gene expression analysis revealed that TAMG and TFH-MG cells are associated with different functional pathways. A higherRORC/FOXP3ratio provided evidence for Th17/Treg imbalance in TAMG potentially related to increasedHIF1A. The hypoxic microenvironment in thymoma may be a driver of T...
(Supplementary Fig.3), potentially because random gains and losses of chromosomes in individual cells were obscured in the bulk population, as expected for non-transformed cells45,46,47. We therefore asked whether analysis of single cells would uncover evidence of aneuploidy. Initial attempts at ...
HCC with CTNNB1 mutation showed a reduction in infiltration score as well as in abundance of certain kinds of immune cells, including CD4 naïve T cells, CD4+ T cells, Tex cells, Th2 cells, Tfh cells, B cells, macrophages, and NK cells. Furthermore, there were 13 chemokines ...
oInutnedretshtianngilny,tFhLeAHGE-KhD3H2 lAab-helCliBng1 bbaycbkogtrhouanndti.bodies was considerably higher in Scientific Reports | 6:27316 | DOI: 10.1038/srep27316 2 www.nature.com/scientificreports/ Figure 1. Immunocytochemical analysis of cells exhibiting cell surface FLAG-hD2 labelling...