本研究旨在评估当前结构数据对TCR-pMHC结合特异性预测的实际作用,尤其是通过计算建模得到的数据。我们提出了一种基于图神经网络的新型机器学习架构STAG(Structural TCR And pMHC binding specificity prediction Graph neural network),利用TCR和pMHC的建模三维结构进行结合特异性预测。实验表明,与其他基于结构和序列的单模态...
TCR-pMHC- Bindingdoi:10.1007/978-1-4419-9863-7_101465TR Recognition of MHC-Peptide ComplexesSpringer New York
近日,生命科学与技术学院生物信息学系、上海自主智能无人系统科学中心刘琦教授课题组在国际人工智能领域顶级期刊Nature Machine Intelligence上发表了题为:Pan-Peptide Meta Learning for T-Cell Receptor-Antigen Binding Recognition的论文,发布了普适有效的抗原-TCR亲和力预测的AI模型PanPep。面向上述pMHC-TCR亲和力识别中...
Considering the physical restriction imposed by the 2D plasma membrane on TCR binding with pMHC,22,47we questioned whether in situ 2D binding affinity could better correlate with TCR specificity. To address this, we characterized the 2D effective binding affinities of the three TCRs individually inte...
T细胞受体(T-cell receptor, TCR)是获得性免疫过程中的关键分子,TCR经过特定的基因重组和进化筛选,具备高度的多样性及特异性,MHC-多肽复合物与TCR亲和力的计算识别(pMHC-TCR binding recognition)是。
研究发现，尽管MHC-间质促进了αβ T细胞分化，但pMHC - preTCR相互作用的缺失导致与去分化相关的胸腺细胞转录编程异常相关。具有T细胞淋巴母细胞和髓系恶性肿瘤先兆特征的高增殖DN和DP亚群出现。在B2m/H2-Ab1 MHC敲除小鼠中，多种MHC Ib类蛋白的代偿性上调在一定程度上保障了体内胸腺细胞的进展，尽管随着年龄的增长...
TCR–pMHC binding interface, which enables force-enhanced CD8 coreceptor binding to MHC-α1α2domains through sequential conformational changes induced by force in both the MHC and CD8. Conversely, engineered high-affinity TCRs create rigid, tightly bound interfaces with cognate pMHCs of their ...
Binding of peptide/MHC (pMHC) complexes by TCR initiates T cell activation. Despite long interest, the exact relationship between the biochemistry of TCR/pMHC interaction (particularly TCR affinity or ligand off-rate) and T cell responses remains unresolved, because the number of complexes examined ...
T细胞受体(T-cell receptor, TCR)是获得性免疫(免疫)过程中的关键分子。TCR经过特定的基因重组和进化筛选,具备高度的多样性及特异性。MHC-多肽复合物与TCR亲和力的计算识别(pMHC-TCR binding recognition)是揭示肿瘤、自身免疫性疾病和病毒感染性疾病等疾病发生发展机制的重要手段,也是计算免疫学领域基本而又极具挑战的...
近日,美国哈佛大学医学院丹娜法伯癌症研究院EllisLReinherz团队在Nature上发表题为Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation的文章,在支持基质上存在或不存在pMHC情况下,培养同步的胎儿胸腺祖细胞,在胸腺细胞发育转变时确定其...