LIU Qing-jun,GAO Bin.Manipulation of MHC-I/TCR Interaction for Immune Therapy. Cellular Molecular Immunology . 2008Liu QJ and Gao B (2008). Manipulation of MHC-I/TCR interaction for immune therapy. Cell Mol Immunol 5, 171-182.LIU Qing-jun,GAO Bin.Manipulation of MHC-I/TCR Interaction ...
Other types of immunotherapies targeting the TCR-peptide/MHC Although TCR-T is the most common immunotherapy strategy targeting the TCR-peptide/MHC interaction, other TCR-based immunotherapy strategies have also been explored for clinical application. All of these strategies utilize a soluble TCR at on...
T细胞进展TCR-MHC(2015)T细胞识别抗原的分子基础 一、TCR及其共受体二、MHC分子及其与抗原肽的相互作用三、MHC多聚体及其应用 T细胞识别抗原是适应性免疫应答发生的先决条件 •T细胞识别抗原的物质基础是其表面的TCR•TCR识别的配体是抗原肽-MHC分子复合物(pMHC)•TCR识别需要CD4/CD8分子作为共受体...
5h). These interactions may be compromised in the context of HLA-A2/MAGEA8, where the positive charge of R65 is neutralized by its interaction with peptide D4. Taken together, our structural data indicate that preferential binding by these TCRs for MAGEA4 is likely due to interactions that ...
Instead, it is more likely that the second site also takes part in an interaction with the TCR. SEH has evolved to expose two different interaction sur- faces, and it cannot be ruled out that these surfaces enable a less specific, weaker interaction. However, it should be kept in mind ...
Sedimentation equilibrium analytical ultracentrifugation, well suited for characterizing weak equilibria, was thus used to characterize this interaction. Figure 1A shows centrifugation of a mixture of the A6 αβTCR and P6A/HLA-A2 along with a fit to a 1:1 binding model; the residuals below the ...
Thus, reduced interaction with the appears to be a transferable feature of the -independent TCRbeta chain. In addition, these findings demonstrate that reactivity to is preferred over the reactivity to MHC during the formation of the repertoire. 展开 ...
该研究以「Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning」为题,于 2023 年 3 月27 日发布在《Nature Machine Intelligence》。 T 细胞对表位的识别在适应性免疫反应中起着至关重要的作用。由主要组织相容性复合体(MHC)分子呈递的致病肽被 T 细胞受体(TCR)...
Here, we utilize such data to train a sequence-based predictor of the interaction between TCRs and peptides presented by the most common human MHCI allele, HLA-A*02:01. Our model is based on convolutional neural networks, which are especially designed to meet the challenges posed by the ...
(TCR) repertoire of innate CD4+ T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte–thymocyte (T-T) interaction (T-T CD4+ T cells) is essential for predicting the characteristics of the antigens that bind to these T cells and for distinguishing T-T CD4+...