文献一《Accurate TCR-pMHC interaction prediction using a BERT-based transfer learning method》,本文由Fresh Wind Biotechnologies团队于2023年11月发表在《Briefings in Bioinformatics》上。文章提出一种基于BERT的新型深度学习模型来预测TCR抗原结合识别。 主要组织相容性复合物(MHC)分子呈现的抗原表位被T细胞受体(TCR)...
1、T cells acquire a regulatory phenotype when their T cell receptors (TCRs) experience an intermediate-high affinity interaction with a self-peptide presented on MHC. 2、Using TCR sequences from FACS-sorted human cells, we identified TCR features that shape affinity to these self-peptide-MHC c...
T细胞进展TCR-MHC(2015)T细胞识别抗原的分子基础 一、TCR及其共受体二、MHC分子及其与抗原肽的相互作用三、MHC多聚体及其应用 T细胞识别抗原是适应性免疫应答发生的先决条件 •T细胞识别抗原的物质基础是其表面的TCR•TCR识别的配体是抗原肽-MHC分子复合物(pMHC)•TCR识别需要CD4/CD8分子作为共受体...
Manipulation of MHC-I/TCR interaction for immune therapy. Cell Mol Immunol 5, 171-182.LIU Qing-jun,GAO Bin.Manipulation of MHC-I/TCR Interaction for Immune Therapy. Cellular Molecular Immunology . 2008LIU Qing-jun,GAO Bin. Manipulation of MHC-I/TCR interaction for immune therapy [ J ]. ...
therefore, this pathway has been widely explored to eliminate tumor- and virus-infected cells [17,18]. Numerous studies have demonstrated the feasibility of eliminating tumor cells via tumor antigen-specific T cells by targeting the TCR-peptide/MHC interaction on the tumor cell surface [19,20,21...
2022年4月8日,Nature Methods在线发表中国医学科学院系统医学研究院/苏州系统医学研究所(简称“系统所”)题为“Engineered retroviruses map ligand-receptor interactions”的评述性文章,系统介绍了近期Nature Methods杂志发表的“Antigen identific...
1. 目标抗原肽刺激健康志愿者的PBMC,合成pMHC四聚体后捕获抗原特异性T细胞。此处抗原肽来自CD20,由HLA-A*02:01呈递。我们提供该过程服务。 2. 单细胞TCR测序捕获抗原特异性T细胞后,根据主克隆的TCR序列构建TCR载体。我们提供TCR表达载体构建服务。 3. 转染原代...
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes ...
The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development
原,而且还可以识别肿瘤细胞内MHC所呈递的抗原肽。因此,在实体瘤治疗 方面具备独特的优势。此外,由于使用天然的TCR还不会产生类似CAR-T免 疫疗法所导致的毒副作用,降低了细胞毒性的风险。 图1-3展示了TCR-T和CAR-T免疫治疗方法的流程图 1.1.3TCR-T的工作原理和发展背景 TCR-T全称叫做T细胞受体基因工程改造的T...