T-cell receptor peptide-MHC interactions: biological lessons from structural studies. Curr Opin Biotechnol. 1998 Aug; 9 (4):338–343.K.C. Garcia, L. Teyton, T-cell receptor peptide-MHC interactions: biological
Stem cell–immune cell cross-talk Ioana Visan Research Highlights11 Dec 2018Nature Immunology Volume: 20, P: 1 T cell help to stem cells CD4+T cell cytokines in the intestinal crypts balance intestinal stem cell renewal and differentiation. ...
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol. 2007; 8 (8):835–844. doi: 10.1038/ni1490. [ Cross Ref ]Skokos D et al (2007) Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph...
T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. Cell Signal - Zhou, KonigZhou W., Konig R. T cell receptor‐independent CD4 signalling: CD4–MHCII interactions regulate intracellular calcium and cyclic AMP. Cell Signal. 2008;...
Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture.MHC class I, MHC class II, T cell epitope, peptide ligand, binding affinity, CTL, epitope recognitionThis unit describes a technique for the direct and quantitative measurement of the capacity of peptide ligands...
These findings show, for the first time to our knowledge, the existence of regulatory mechanisms that direct the responding CD8+ T-cell repertoire toward epitopes with high-stability interactions with MHC class I molecules. They also provide an insight into factors that facilitate CD8+ T-cell ...
4a), we reasoned that CLTCH129>Q-specific CD4+ T cell-mediated protection may be dependent on their role as helper cells for CD8+ T cells19. Consistent with this, depletion of CD8+ T cells before the transfer of CD4+ T cells and tumor inoculation prevented tumor rejection (Fig. 4f). ...
Autophagy and endo-/exosomal pathways are intertwined in a highly intricate manner and both are closely involved in antigen processing for MHC presentation; thus, we propose that they may coordinate in antigen processing and presentation in anticancer T cell immune responses. In this article, we ...
摘要: The transduction signals from the immobilisation of a class I heavy chain, HLA-A2, on a layer guided acoustic plate mode device, followed by binding of β2-microglobulin and subsequent selective binding of a target peptide are reported....
1.Introduction2.StructureofMHCgenesandproducts3.PolymorphismofMHC4.InteractionsofMHCmoleculeswith antigenicpeptides5.BiologicalfunctionofMHCmolecules6.MHCandclinicalmedicine MHC Introduction 1.HistocompatibilityantigenTheAgsprimarilyresponsibleforrejectionofgeneticallydifferenttissuesareknownashistocompatibilityAgs....