One of the most adaptive immune responses is triggered by specific T-cell receptors (TCR) binding to peptide-major histocompatibility complexes (pMHC). Despite the availability of many prediction approaches to identify peptides binding to MHC, they are often lack of peptide-TCR interactions and ...
Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen Vadim K. Karnaukhov Dmitrii S. Shcherbinin Mikhail Shugay Nature Computational Science(2024) Can AlphaFold’s breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?
Despite the availability of many prediction approaches to identify peptides binding to MHC, they are often lack of peptide-TCR interactions and detailed atomic interacting models. Due to an increasing number of high-throughput binding epitopes and TCR-peptide-MHC (TCR-pMHC) structural complexes are ...
The method specifically targets the prediction of binding specificity between neoantigens and TCR within Class I MHC complexes. By analyzing TCR sequences, antigens and Class I MHC alleles, this study not only achieves accurate prediction of pairing but also significantly enhances computational ...
To improve the predictability of immunogenic neoantigens, we developed the in silico neoantigen prediction workflows VACINUSpMHC and VACINUSTCR: VACINUSpMHC incorporates physical binding between peptides and MHCs (pMHCs), and VACINUSTCR integrates T cell reactivity to the pMHC complex through deep...
These results suggest that TCR-pMHC binding prediction remains highly challenging and requires further high quality data and novel algorithmic approaches.Deng, LihuaLy, CedricAbdollahi, SinaYu ZhaoPrinz, ImmoBonn, StefanFrontiers in Immunology