在免疫检查点抑制治疗中,TCF+前体细胞在CD8+T细胞响应中起着关键作用,作者研究是否SIY特异性细胞在这一治疗过程中也起着关键作用。在一周抗PD-1/CTLA-4治疗后,T细胞增殖更为明显,其动态变化与TCF1+前体T细胞基本相反。也就是说,免疫检查点...
在免疫检查点抑制治疗中,TCF+前体细胞在CD8+T细胞响应中起着关键作用,作者研究是否SIY特异性细胞在这一治疗过程中也起着关键作用。在一周抗PD-1/CTLA-4治疗后,T细胞增殖更为明显,其动态变化与TCF1+前体T细胞基本相反。也就是说,免疫检查点治疗使得细胞类型由TCF1+向TCF1-转变。但是,虽然TCF1+细胞比例逐渐降低,...
These so-called stem-like CD8+ T-cells, which give rise to effector cells, were shown to be essential for the clinical response to PD-1 blockade. How radiotherapy influences the different CD8+ T-cell subsets in the tumor microenvironment has not been comprehensively investigated. We propose ...
PD-1transcriptional circuitCD8 T cell exhaustionimmunotherapyTCF-1 is a key transcription factor in progenitor exhausted CD8 Tcells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate ...
本文利用小鼠模型证明了——肿瘤中存在一群TCF1+ T细胞亚群,PD-1治疗有效主要是通过促进该群细胞发生增殖活化后产生的抗肿瘤作用。 Title: An intra-tumoral niche maintains and differentiates stem-like CD8 T cells Pubication Data: 2019/12/11 Journal: Nature ...
流式分析表明淋巴结CD8+T细胞内TOX表达随SIV感染时间延长而显著增加,尤其在CD95+记忆性CD8T细胞(memory CD8+T,TM)。与此同时,流式分析进一步发现淋巴结内 TOX+CD8+TM呈现GzmB+TCF-1-CD39+PD-1+TIGIT+TIM3+CD101+(传统效应...
Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due to the exhaustion of CD8+ T cells in the tumor microenvironme
CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells. Multiomics analyses showed that Tcf1 recruited the gen
In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8+ T cells generated in response to viral or tumour antigens, and for preserving heightened responses to checkpoint blockade immunotherapy. In the helper T cell lineages, TCF1 is indispensable for the ...
1免疫检查点阻断治疗的早期耗竭亚群,因此敲除Id2显著抑制了PD-1抗体的抑瘤效果.结果表明,Id2分子可以调控早期耗竭CD8+T细胞的产生及其向终末耗竭细胞的转化.第三... 李一鸣 - 中国人民解放军空军军医大学 被引量: 0发表: 2022年 转录因子Bach2在慢性感染引起的耗竭性T细胞分化中的机制研究 背景:在慢性感染或肿...