流式分析表明淋巴结CD8+T细胞内TOX表达随SIV感染时间延长而显著增加,尤其在CD95+记忆性CD8T细胞(memory CD8+T,TM)。与此同时,流式分析进一步发现淋巴结内 TOX+CD8+TM呈现GzmB+TCF-1-CD39+PD-1+TIGIT+TIM3+CD101+(传统效应...
在免疫检查点抑制治疗中,TCF+前体细胞在CD8+T细胞响应中起着关键作用,作者研究是否SIY特异性细胞在这一治疗过程中也起着关键作用。在一周抗PD-1/CTLA-4治疗后,T细胞增殖更为明显,其动态变化与TCF1+前体T细胞基本相反。也就是说,免疫检查点...
流式分析表明淋巴结CD8+T细胞内TOX表达随SIV感染时间延长而显著增加,尤其在CD95+记忆性CD8T细胞(memory CD8+T,TM)。与此同时,流式分析进一步发现淋巴结内 TOX+CD8+TM呈现GzmB+TCF-1-CD39+PD-1+TIGIT+TIM3+CD101+(传统效应T细胞,effector T, TEFF)和GzmK+GzmBlowTCF-1highCD39+PD-1+TIGIT+TIM3+CD101+...
To improve anti-TSA immunity while limiting anti-SSA autoreactivity, we need to understand how tumor-specific CD8+ T cells (TST) and SSA-specific CD8+ T (SST) cells differentiate in response to cognate antigens during tumorigenesis. Therefore, we developed a genetic cancer mouse model in ...
Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due to the exhaustion of CD8+ T cells in the tumor microenvironme
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537, 417–421 (2016). Article CAS PubMed PubMed Central Google Scholar Utzschneider, D. T. et al. T cell factor 1-expressing memory-like CD8(+) T cells sustain the immune response to chronic viral ...
maintain effector function [7,8,9]. Studies have also reported that TCF-1 + CD8 T cells with stem-like abilities express low levels of PD-1 and Tim checkpoint receptors, further providing evidence that TCF-1 is required for CD8 T cell formation and persistent function [10,11,12]. ...
在肿瘤免疫检查点抑制治疗(例如抗PD-1)后,新抗原特异性CD8+T细胞增殖明显,并且,这一增殖与新抗原水平正相关【2】;而靶向新抗原的过继性T细胞治疗可以明显起到抗癌作用【3,4】。这些结果表明,靶向新抗原的免疫治疗方法在癌症治疗方面,尤其是癌症疫苗研发方面,有着十分广阔的前景。但是,其具体机制,以及如何应用于...
TCF-1 is a key transcription factor in progenitor exhausted CD8 Tcells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. ...
近日,美国哈佛医学院医学科学系的研究人员在 Cancer Cell期刊发表了题为:Tumor immunogenicity dictates reliance on TCF1 in CD8 + T cells for response to immunotherapy的研究论文。干细胞样CD8+T细胞受T细胞因子1(TCF1)调控,与对免疫检查点阻断(ICB)的响应密切相关。然而,在不同的肿瘤背景中,ICB疗效对TCF1+...