而且临床试验中确实延长了部分患者生存期(有的长达5年以上),这一直是一个令人困扰的问题。 2. TCF1+ TIL subset在PD-1治疗中发挥作用 Title: Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy Pubication ...
PD-1+ TIM-3-SLAMF6 low/neg CX3CR1+ 早期效应细胞(亚群2)、PD-1+ TIM-3+ CD39low/neg SLAMF6 + 预功能障碍细胞(亚群3)和PD-1+ TIM-3+ CD39+ SLAMF6- 终末功能障碍细胞(亚群4)。
多项证据指出,新抗原(neoantigen),也就是来自于主要组织相容性分子突变后所产生的多肽,可以驱动T细胞对肿瘤进行应答【1】。在肿瘤免疫检查点抑制治疗(例如抗PD-1)后,新抗原特异性CD8+T细胞增殖明显,并且,这一增殖与新抗原水平正相关【2】;而靶向新抗原的过继性T细胞治疗可以明显起到抗癌作用【3,4】。这些结果表明...
Phenotypic, functional, and transcriptome analyses show that TML-derived memory cells resemble those arising in response to acute, resolved infection, but they retain features of chronically stimulated cells, including elevated PD-1 and Tox and reduced cytokine expression. This chronic infection imprint ...
在CD4+细胞中,TCF1+的细胞也表现出对等分裂,但是这种细胞是否为持续的CD4+T细胞的来源还不清楚。 持续的慢性抗原刺激产生CD4+PD-1+ T细胞; 其中祖细胞样的细胞是Tfh和Teff的来源; TCF1+祖细胞分化依赖于BCL6; TCF1+ CD4+ T细胞对于...
在TCF-1缺陷的Treg中,不论是TCF-1结合的还是TCF-1+Foxp3都结合的分子表达水平明显升高,这表明这些基因可能在Treg中受TCF-1调控(d),进一步用Chip-seq确认了染色质的开放程度(e)。 进一步通过流式确认表型发现Treg的激活表型增加(CD69、ICOS、PD-1、CD44等)(a),TCF-1的缺失...
研究报道PD-1阻断促进干细胞样CD8+T细胞增殖和向TEFF分化【6】。作者发现PD-1抑制剂确实显著增加TCF1+CD39+CD8+TM和TCF1-CD39+TEFF比例,但Ki-67的增加仅在TCF1+CD39+CD8+TM细胞。这些结果表明TCF1+CD39+CD8+TM是一种有干细胞特性的中间效应细胞群,且具有向TEFF分化的能力。
TCF-1 mediated a T-bet-to-Eomes transcription factor transition in Tex precursors by promoting Eomes expression and drove c-Myb expression that controlled Bcl-2 and survival. These data define a role for TCF-1 in early-fate-bifurcation-driving Tex precursor cells and also identify PD-1 as a...
potentially explaining their localization in B cell follicles. CXCR5 was found on both Tcf1+and Tcf1−cells (Supplementary Fig.2a, b), unlike observations in chronic LCMV infection, where Tcf1 expression was correlated with CXCR5 expression31. Both Tcf1+and Tcf1−cells expressed PD-1 in ch...
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