T-cell dysfunctionTumor microenvironmentThe failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two...
T cell senescence and T cell exhaustion as potential biomarkers of progression-free and overall survival in patients with recurrent ovarian cancer treated with anti-PD1 combination therapy 复发性卵巢癌患者抗PD1联合治疗中T细胞衰...
T cell immunotherapies demonstrate impressive activity against some cancers, but durable responses are not achieved in most patients. A central barrier to progress is inadequate T cell potency to eradicate large tumor burdens, w...
④The state involves an early block in tyrosine kinase activation, which predominantly inhibits calcium mobilization, and an independent mechanism that blocks signaling through the IL-2 receptor 3. T cell senescence 肿瘤细胞与浸润至肿瘤组织中的淋巴细胞在微环境中竞争有限的葡萄糖,通过限制淋巴细胞对葡萄...
Progressive development of T cell exhaustion. Exhausted耗竭T细胞是T细胞分化的独特细胞系,来源于CD127+记忆前体细胞,在表型和机制上与其他T细胞功能障碍(如无能anergy和衰老senescence)不同。 感染后,幼稚T细胞被抗原、共刺激(co-stimulation)和炎症激活,它们呈指数级增殖,形成效应群体。
senescence, exhaustion, regulatory CD4+T cells, and memory stem T cells (TSCM). Data obtained with this gating strategy were then analyzed by appropriate, non-parametric statistical tests, and represented in the figures as scatter plots with means and standard errors of the mean. In the second...
CAR-T cells can experience exhaustion and senescence, leading to diminished function and reduced effectiveness of the therapy. Understanding and addressing T cell exhaustion is crucial for maximizing the long-term efficacy of CAR-T cell therapy [67]. ...
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional e
The number of beads to cells, called bead-to-cell ratio, is a determinant of signal strength and consequently T cell expansion. While extremely high bead-to-cell ratio results in T cell exhaustion, too low ratios fail to activate T cells, both resulting in a suboptimal T cell expansion [...
4. Zhao Y, Shao Q, Peng G. Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment.Cell Mol Immunol.2020 Jan;17(1):27-35. doi: 10.1038/s41423-019-0344-8. Epub 2019 De...