Dean M. Cancer stem cells: implications for cancer causation and therapy resistance. Discov Med. 2005;5:278-82.Cancer stem cells: Implications for cancer causation and therapy resistance. Discovery Medicine 2005 - Dean () Citation Context ... transporter proteins which are the major multidrug ...
the phenotypic heterogeneity of colorectal cancer remains poorly explored. Our study identifies oncofetal reprogramming of neoplastic stem cells, driven by the transcription factors YAP and AP-1, as a critical driver of phenotypic heterogeneity, lineage plasticity and therapy resistance. Targeting the on...
Proteintech Blog: Cancer Stem Cells | CSCs are cancerous yet have properties of stem cells: self-renewal and the ability to differentiate into multiple cell types that occurs in tumors.
(4月10日Nature“How to supercharge cancer-fighting cells: give them stem-cell skills”) CAR T细胞 CAR T细胞(Chimeric Antigen Receptor T cells)是一种通过基因工程改造的T细胞,它们被设计用来识别并杀死癌细胞。这种细胞通过从患者体内提取T细...
Cancer stem cells are likely to share many of the properties of normal stem cells that provide for a long lifespan, including relative quiescence, resistance to drugs and toxins through the expression of several ABC transporters, an active DNA-repair capacity and a resistance to apoptosis. Therefo...
2024年4月24日,来自美国希望之城国家医疗中心血液学与造血细胞移植科的Jianhua Yu与Michael A. Caligiuri共同在Cell Stem Cell期刊发表题为Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer(人类抗PS...
Extract: The discovery that many cancers arise from alterations of the body's normal stem cells is changing our views of cancer causation as well as therapy. Stem cells have a unique capacity for self-renewal; with each division they give rise to cells with the same differentiation potential ...
Studeny, M. et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-β delivery into tumors.Cancer Res.62, 3603–3608 (2002). CASPubMedGoogle Scholar Ren, C. et al. Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung...
Accordingly, CSC express specific markers that vary considerably depending on tumor type and tissue of origin but there is no universal marker for CSC [7,8]. The CSC model of cancer considers tumors as a plastic process, where normal cancer cells can de-differentiate into CSC, e.g. as a ...
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand ...