Cancer stem cellsEMT and TMETherapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contribute to poor prognosis. Therapy resistance can be both intrinsic ...
Therapy resistance can be both intrinsic and/or acquired. These are multifactorial events, and some are related to factors including adaptations in cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT), deregulation of key signaling pathways, drug efflux through ABC transporters, acquired ...
Stem cells (SCs) maintain tissue homeostasis using the unique property of self-renewal [8]. Drug resistance and cancer relapse are occurred due to the presence of a type of stem cells called cancer stem cells (CSCs) within a tumor with the ability to generate heterogeneous lineages of cancer ...
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand ...
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated cancer cells exhibiting stem cell-like features (CSCs). Epithelial to... A,Singh,J,Settleman - 《Oncogene》 被引量:...
Therefore, tumours might have a built-in population of drug-resistant pluripotent cells that can survive chemotherapy and repopulate the tumour. Abstract The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have...
response and drug resistance of melanoma cells T Redmer1,2, I Walz2, B Klinger2,3, S Khouja2, Y Welte2, R Schäfer1,2 and C Regenbrecht2,4 Several lines of evidence have suggested that stemness and acquired resistance to targeted inhibitors or chemotherapeutics are mechanistically linked....
Proteintech Blog: Cancer Stem Cells | CSCs are cancerous yet have properties of stem cells: self-renewal and the ability to differentiate into multiple cell types that occurs in tumors.
Cancer stem cells (CSCs) are rare population of cells that are bestowed with the capability to generate itself bypassing the cell cycle checkpoint mechanisms and are implicated in tumor initiation, metastasis, and relapse or drug resistance.
Cancer Stem Cells (CSCs) are a minor group of cells in tumors that have self-renewal, differentiation, and tumorigenicity properties. Some known markers such as CD44, CD24, and CD133 on the cell membrane are often used to identify and enrich CSCs in seve