POPULATION CELLSPROGENITOR CELLSBREAST-CANCERADRENOCORTICALCARCINOMAFOLLICULOSTELLATE CELLSIN-VITROCancer stem-like cells are a subpopulation of self-renewing cells that are more resistant to chemotherapy and radiation therapy than the other surrounding cancer cells. The cancer stem cell model predicts that ...
Intravital imaging of cancer stem cell plasticity in mammary tumors. Stem Cells 31, 602–606 (2013). Article CAS PubMed Google Scholar Chen, J. et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522–526 (2012). Article CAS PubMed PubMed ...
clinical variability, and transcriptomic diversity have stalled the progress in achieving diagnostic, prognostic, and therapeutic breakthroughs. In comparison to other solid malignancies, the mainstay in the treatment of PC is still the conventional chemotherapy, involving the gemcitabine (GEM) plus nab-p...
Targeted therapies are generally better tolerated than traditional chemotherapy. Targeted therapy has raised new questions about the tailoring of cancer treatment to an individual patient’s tumor, the assessment of drug effectiveness and toxicity, the economics of cancer care, and resistance following ...
“To us, it makes sense that the same processes that protect normal stem cells also exist in cancer stem cells to make them resistant to chemotherapy. We need to develop new ways to target the specific biology of cancer stem cells to prevent the continued production of mature tumor cells ...
Targeting cancer stem cells for more effective therapies: taking out cancer's locomotive engine Biochem Pharmacol, 78 (2009), pp. 326-334 Google Scholar 56 S. Raguz, E. Yague Resistance to chemotherapy: new treatments and novel insights into an old problem Br J Cancer, 99 (2008), pp. 387...
(TMZ), the most commonly used antiglioma chemotherapy, consistently expands the glioma stem cell (GSC) pool over time in both patient-derived and established glioma cell lines, which has been shown to be a result of phenotypic and functional interconversion between differentiated tumor cells and ...
Chemotherapy is one of the principal modes of treatment for cancer, but resistance to chemotherapeutic drugs is a hallmark of malignant tumors that results in major limitation in chemotherapy1,2. Cancer stem cells (CSCs) or tumor-initiating cells (TICs) are a self-renewing, highly tumorigenic sub...
Exploring YAP1-related TIME in SCLC: implications for survival and treatment response to immuno-chemotherapy Abstract: Aim:Small-cell lung cancer (SCLC) is usually diagnosed as an advanced stage with a poor outcome. SCLC has limited response to immunotherapy due to the...MORE ...
These cells are named cancer stem cells [65]. It is hypothesized that cancer stem cells can survive from common treatments like chemotherapy and also have self-renewal abilities [64,66], so from the aforementioned data, we can conclude that targeting cancer stem cell antigens may lead to ...