Advances in stem cell biology over the last two decades have provided new insights into cancer biology1,2,3. Tumors show markedheterogeneity in morphology, proliferation rates, genetic lesions and therapeutic response. Thus, not all tumor cells are equal.This heterogeneity is even seen in an ...
先后主持国家自然基金 3 项,省部级科研课题 4 项,其他项目 5 余项,在 Nature Medicine,Cell stem Cell,Cancer Res, Nucleic Acids Research, Oncogene, Cancer Letter 等杂志发表科研论文 110 余篇,其中 SCI 收录论文 40 篇.获得 2 项省级成果,培养博士研究生 8 名,硕士研究生 30 名,在站博士后 1 人. ...
Regulation of cell polarity during epithelial morphogenesis. Curr. Opin. Cell Biol. 20, 227–234 (2008). Article CAS PubMed Google Scholar Lee, M. & Vasioukhin, V. Cell polarity and cancer--cell and tissue polarity as a non-canonical tumor suppressor. J. Cell Sci. 121, 1141–1150 (...
and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer. ...
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Latest Research and Reviews Lfng-expressing centroacinar cell is a unique cell-of-origin for p53 deficient pancreatic cancer Wen-Cheng Chung Shubing Zhang Keli Xu ResearchOpen Access15 Nov 2024Oncogene P: 1-15 Targeting DDX3X eliminates leukemia stem cells in chronic myeloid leukemia by blocking ...
The discovery of cancer stem cells (CSC) in certain tumor types launched a new discipline within cancer research. Many scientists are now looking to identify and characterize populations of tumor cells which have acquired stem cell–like properties as potential sources of metastasis and therapeutic re...
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Research articleOpen archive A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer Benjamin T. Spike, Dannielle D. Engle, Jennifer C. Lin, Samantha K. Cheung, ... Geoffrey M. Wahl ...
Table 3. Growth characteristics of cellular models for colon cancer. 2.1. Mechanistic Assays Several mechanistic assays that have been optimized for the parental cell lines and also for stem cells are widely used in preclinical cancer research. The assays for parental cell lines involve monitoring ...