pyrimidine-rich RNA may contribute to the selection of specific splice sites97. U2AF65 and its related protein CAPERα (also known as RBM39) show cooperative binding to splicing factor 3b subunit 1 (SF3B1). U2AF65 forms liquid-like condensates through its SR-rich domain, and condensation is...
et al. Mutant splicing factor 3b subunit 1 (SF3B1) causes dysregulated erythropoiesis and a stem cell disadvantage. Blood Abstr. 124, 828 (2014). Article Google Scholar Mupo, A. et al. Sf3b1 K700E mutation impairs pre-mRNA splicing and definitive hematopoiesis in a conditional knock-in ...
Splicing factor 3b, subunit 1 SRSF2: Serine/arginine-rich splicing factor 2 U2AF1: U2 small nuclear RNA auxiliary factor 1 BCL-2: B cell lymphoma 2 IAP: Inhibitor of apoptosis BIM: Bcl-2-like protein 11 SRSF1: Serine/arginine-rich splicing factor 1 mTORC1: Mammalian target of...
The transcription factor forkhead box P2 (FOXP2) is of particular interest as a potential driver of human language function, as it harbors two amino acid substitutions present in humans but not in chimpanzees and many other mammalian genomes. Families with FOXP2 mutations exhibit severe speech defe...
et al. The role of rna splicing factor ptbp1 in neuronal development. Biochim. Biophys. Acta Mol. Cell Res. 1870, 119506 (2023). Article CAS PubMed Google Scholar Golanska, E. et al. Analysis of APBB2 gene polymorphisms in sporadic Alzheimer’s disease. Neurosci. Lett. 447, 164–166...
英文名称: SF3B2 (Splicing Factor 3B Subunit 2, Cus1, SF3b1, SAP145, SF3B145, SF3b150) (HRP) 英文同义词: SF3B2 (Splicing Factor 3B Subunit 2, Cus1, SF3b1, SAP145, SF3B145, SF3b150) (HRP) CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按...
Spliceosome assembly. Five small nuclear ribonucleoproteins (snRNPs) and various auxiliary proteins interact with pre-mRNA in a specific order to form the spliceosome. The U1 snRNP is recruited to the 5’ splice site, whereas splicing factor 1 (SF1), U2 auxiliary factor 2 and 1 (U2AF2 and ...
Here we identified splicing factor 3b subunit 4 (SF3b4) as a molecule that interacts with BMPR-IA, using a yeast two-hybrid screening with a human fetal brain cDNA library. Co-immunoprecipitation/immunoblot analysis confirmed their interaction in mammalian cells. By separation of the cell ...
Surprisingly, Snu17p, the proposed yeast orthologue of the seventh human SF3b subunit, p14, was not found in the yeast complex. TAP purification revealed that Snu17p, together with Bud13p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex. Subunits of this complex...
et al. Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk myelodysplastic syndromes with ring sideroblasts. J. Hematol. Oncol. 7, 89 (2015). Google Scholar Matsunawa, M. et al. Haploinsufficiency of Sf3b1 leads to compromised stem cell function but ...