Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathwayGuoming DengYufeng LuoYaoming ZhangJinfeng ZhangZongyun He
et al. Mutant splicing factor 3b subunit 1 (SF3B1) causes dysregulated erythropoiesis and a stem cell disadvantage. Blood Abstr. 124, 828 (2014). Article Google Scholar Mupo, A. et al. Sf3b1 K700E mutation impairs pre-mRNA splicing and definitive hematopoiesis in a conditional knock-in ...
The first one is about mutations affecting directly a splicing factor, which impairs specific or general splicing reactions. Often, such mutation is lethal, illustrating the dependence of cells for splicing. Indeed, splicing factors U2AF35 or SF3b subunit 4 have been shown to be essential during...
In this work, we have identified splicing factor 3B subunit 1 (SF3B1) as a potential target for this approach. SF3B1 interacts with the viral protein Tat, which is critical for viral transcription. Inhibition of SF3B1 prevents HIV transcription and reactivation from latency. Since there are ...
Splicing factor 3b, subunit 1 SRSF2: Serine/arginine-rich splicing factor 2 U2AF1: U2 small nuclear RNA auxiliary factor 1 BCL-2: B cell lymphoma 2 IAP: Inhibitor of apoptosis BIM: Bcl-2-like protein 11 SRSF1: Serine/arginine-rich splicing factor 1 mTORC1: Mammalian target of...
respectively. The U2AF heterodimer facilitates the substitution of SF1 with U2 small ribonucleoprotein (U2 snRNP) at the BPS after binding to the 3’ ss and PPT. The splicing factor 3B (SF3B), which is a protein subcomplex in the U2 snRNP, interacts with the nucleotide sequence that surrou...
Interestingly, ZCCHC8 has also been shown to interact with the cap-binding complex (CBC) and several members of the SR protein family21, and one study has reported that, in vitro, RBM7 interacts with the splicing factor 3b subunit 2 (SAP145) and the SRSF3 protein26. The interaction ...
respectively. The U2AF heterodimer facilitates the substitution of SF1 with U2 small ribonucleoprotein (U2 snRNP) at the BPS after binding to the 3’ ss and PPT. The splicing factor 3B (SF3B), which is a protein subcomplex in the U2 snRNP, interacts with the nucleotide sequence that surrou...
SFPQ (Splicing Factor, Proline- and Glutamine-rich, 100kD DNA-pairing Protein, hPOMp100, DNA-binding p52/p100 Complex, 100kD Subunit, Polypyrimidine Tract-binding Protein-associated-splicing Factor, PSF, PTB-associated-splicing Fact, PSF) (PE)化学性质...
The splicing factor 3b subunit 1 (SF3B1) protein is a core component of the U2 snRNP at the catalytic center of the spliceosome, which recognizes and defines the 3′ splice site at the intron-exon junctions4. Through pre-mRNA splicing, a single pre-mRNA transcript may give rise to ...