et al. Mutant splicing factor 3b subunit 1 (SF3B1) causes dysregulated erythropoiesis and a stem cell disadvantage. Blood Abstr. 124, 828 (2014). Article Google Scholar Mupo, A. et al. Sf3b1 K700E mutation imp
"Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts." J Hematol Oncol 7: 89....
The first one is about mutations affecting directly a splicing factor, which impairs specific or general splicing reactions. Often, such mutation is lethal, illustrating the dependence of cells for splicing. Indeed, splicing factors U2AF35 or SF3b subunit 4 have been shown to be essential during...
respectively. The U2AF heterodimer facilitates the substitution of SF1 with U2 small ribonucleoprotein (U2 snRNP) at the BPS after binding to the 3’ ss and PPT. The splicing factor 3B (SF3B), which is a protein subcomplex in the U2 snRNP, interacts with the nucleotide sequence that surrou...
Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP. PLoS One 2009; 4: e7202. Article PubMed PubMed Central Google Scholar Golas MM, Sander B, Will CL, Luhrmann R, Stark H . Molecular architecture of the multiprotein splicing factor SF3b. Science 2003; 300:...
Splicing factor 3b, subunit 1 SRSF2: Serine/arginine-rich splicing factor 2 U2AF1: U2 small nuclear RNA auxiliary factor 1 BCL-2: B cell lymphoma 2 IAP: Inhibitor of apoptosis BIM: Bcl-2-like protein 11 SRSF1: Serine/arginine-rich splicing factor 1 mTORC1: Mammalian target of...
respectively. The U2AF heterodimer facilitates the substitution of SF1 with U2 small ribonucleoprotein (U2 snRNP) at the BPS after binding to the 3’ ss and PPT. The splicing factor 3B (SF3B), which is a protein subcomplex in the U2 snRNP, interacts with the nucleotide sequence that surrou...
To distinguish between these possibili- ties, we depleted the essential NMD factor UPF1 by siRNA in the C25Cl48 cells and compared the DMD splicing profile with that obtained in eIF4A3- and Y14-depleted cells. UPF1 mRNA and protein levels were efficiently downregulated and we could verify ...
Additionally, METTL16 exists in the cytosol and directly interacts with eukaryotic translation initiation factor 3 subunit A (eIF3a), eIF3b, and ribosomal RNA to promote m6A-independent translation [18]. In U2OS osteosarcoma cells, METTL16 inhibits the exonuclease activity of MRE11 homolog (MRE11...
Interestingly, ZCCHC8 has also been shown to interact with the cap-binding complex (CBC) and several members of the SR protein family21, and one study has reported that, in vitro, RBM7 interacts with the splicing factor 3b subunit 2 (SAP145) and the SRSF3 protein26. The interaction ...