molecule (redirected fromSmall molecule) Thesaurus Medical Encyclopedia Wikipedia mol·e·cule (mŏl′ĭ-kyo͞ol′) n. 1.The smallest particle of a substance that retains the chemical and physical properties of the substance and is composed of two or more atoms; a group of like or differe...
Small-molecule antivirulence agents represent a promising alternative or adjuvant to antibiotics. These compounds disarm pathogens of disease-causing toxins without killing them, thereby diminishing survival pressure to develop resistance. Here we show that the small-molecule antivirulence agents F12 and F19...
1.1Choice of Appropriate Small Molecule Inhibitors In analogy to reversegenetics,small moleculescan be used for the deconvolution of protein function by analyzing the phenotype of compound-treated cells. Compared to most genetic approaches, e.g., RNA interference,small moleculesare superior with respect...
Small-molecule inhibitors that were reported for three representative emerging classes of RBPs, the microRNA-binding protein LIN28, the single-stranded or double-stranded RNA-binding Toll-like receptors and the CRISPR-associated (Cas) proteins, are highlighted from a medicinal-chemistry and chemical-...
Small-Molecule Inhibitors of Staphylococcus aureus RnpA-Mediated RNA Turnover and tRNA Processing New agents are urgently needed for the therapeutic treatment of Staphylococcus aureus infections. In that regard, S. aureus RNase RnpA may represent a prom... Eidem,M Tess,Lounsbury,... 被引量: 0发...
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis[3-(2-N,N-...
Small-Molecule Inhibitors of:小分子抑制剂of,Of,小分子,抑制剂,small,Small 文档格式: .pdf 文档大小: 1.17M 文档页数: 9页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--毕业论文 文档标签: ofOf小分子抑制剂smallSmall ...
Small Molecules In biological sciences, the term small molecule refers to a small non-peptide, organic compound that is biologically active. Small molecules as research materials have many advantages since they can be designed to be selective, potent, water soluble or cell permeable. Consequently ...
1A).Rabbit Polyclonal to INSL4We further analyzed the expression degree of and both which are essential proteins for mitophagy during much longer incubation intervals (Fig.?S2A, B). Time-course tests showed that the quantity of RNA of both and had been reduced at 8-h incubation with SD-Fe...
A. Small-molecule inhibitors of protein–protein interactions: progressing toward the reality. Chem. Biol. 21, 1102–1114 (2014). Article CAS PubMed PubMed Central Google Scholar Lage, K. Protein–protein interactions and genetic diseases: the interactome. Biochim. Biophys. Acta 1842, 1971–...