^Lee J C , Tseng C K , Chen K J , et al. A cell-based reporter assay for inhibitor screening of hepatitis C virus RNA-dependent RNA polymerase[J]. Analytical Biochemistry, 2010, 403(1-2):52-62. ^A Cell-Based Reporter Assay for Screening Inhibitors of MERS Coronavirus RNA-Dependent ...
Within the RNA genome of infections is RNA-dependent RNA polymerase (RdRp), which is an essential enzyme that helps in RNA synthesis by catalysing the RNA template-dependent development of phosphodiester bonds. Therefore, RdRp is an important therapeutic target in RNA virus-caused diseases, ...
2020年4月10日，饶子和院士领导新冠病毒攻关小组（主要成员包括上海科技大学的王权以及清华大学的娄智勇，均为本文的共同通讯作者）在Science杂志发表文章Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target，报告了新冠病毒全长nsp12与辅助因子nsp7和nsp8复合物的冷冻电镜结构，...
均为本文的共同通讯作者)在Science杂志发表文章Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target,报告了新冠病毒全长nsp12与辅助因子nsp7和nsp8复合物的冷冻电镜结构,分辨率为2.9埃(蛋白质结构数据...
RNA dependentRNA polymerase(RdRp) is a multisubunit protein that plays a critical role in the replication and transcription of the viral genome; therefore, RdRp emerges as a primary target to disrupt viral infection. Essentially there are two types of polymerase inhibitors based on their ...
2020年5月1日,中国科学院上海药物研究所徐华强研究员、浙江大学张岩教授、北京协和医院张抒扬教授和上海药物研究所许叶春研究员等合作在Science杂志上发表文章Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir,解析新冠病毒复制酶与瑞德西韦复合物结构(该文章曾于4...
Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications not only for carcinogenesis by RNA viruses but also for the general understanding of gen...
Related to RNA-dependent RNA polymerase:replicase pol·y·mer·ase (pə-lĭm′ə-rās′, -rāz′, pŏl′ə-mə-) n. Any of various enzymes, such as DNA polymerase, RNA polymerase, or reverse transcriptase, that catalyze the formation of polynucleotides of DNA or RNA using an ...
DNA-dependent RNA polymerase 英 美 [ˌdiː en ˈeɪ dɪˈpendənt ˌɑːr en ˈeɪ ˈpɑˌlɪməˌreɪs]网络 依赖DNA的RNA聚合酶; 依赖于dna的rna聚合酶 ...
均为本文的共同通讯作者)在Science杂志发表文章Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target,报告了新冠病毒全长nsp12与辅助因子nsp7和nsp8复合物的冷冻电镜结构,分辨率为2.9埃(蛋白质结构数据库PDB ID:6M71),对于解析高分辨率的病毒RdRp来说,是一个重要的突破...