Small molecule RNase inhibitors and methods of use 优质文献 相似文献 参考文献 引证文献SMALL MOLECULE RNASE INHIBITOR, AND METHOD OF USE PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating or preventing microbial infection. PM Dunman,ダンマン ポール エム.,PD Olson,... 被...
Small-molecule antivirulence agents represent a promising alternative or adjuvant to antibiotics. These compounds disarm pathogens of disease-causing toxins without killing them, thereby diminishing survival pressure to develop resistance. Here we show that the small-molecule antivirulence agents F12 and F19...
SMALL MOLECULE RNASE INHIBITOR, AND METHOD OF USEPROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating or preventing microbial infection.PAUL M DUNMANダンマン ポール エム.PATRICK D OLSONオルソン パトリック ディー.
was screened out. Components with m6A inhibitory activity have been found from natural products such as FTO inhibitor Rhein [19] and METTL3 inhibitor Quercetin [11]. Through rational drug design, a series of small molecule inhibitors targeting FTO, such as FB23, ...
et al. Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat. Chem. Biol. 2, 213–220 (2006). Article CAS PubMed Google Scholar Moerke, N. J. et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. ...
Therefore, we assessed the effects of inhibiting DCLK1 kinase activity using the novel small molecule kinase inhibitor, LRRK2-IN-1, which demonstrates significant affinity for DCLK1. Results Here we report that LRRK2-IN-1 demonstrates potent anti-cancer activity including inhibition of cancer cell...
An and coworkers reported that the small molecule NA inhibitor NSC89853 (11), which is structurally different from other SA mimics, could possibly bind to the pocket formed by the 430-loop based on molecular modeling43. Feng, et al.44 , recently designed and synthesized a series of ...
ALK inhibitors are an attractive small-molecule targeted therapy ALK inhibitor Neuropeptide Y Receptors Eventually, 1 106 cells had been plated into 24-well plates coated with polylysine and incubated at 37 C, 5% CO2 right away posted by:admin ...
PAK4—a member of the PAK family of serine threonine kinases, linked with PI3K/AKT and Wnt/β-catenin signaling—has been identified as a promising therapeutic target in cancer [211,212]. With two small molecule inhibitors of PAK4 currently being evaluated in Phase I basket trials in solid ...
proteins for the purpose of improving their pharmaceutical utility is perhaps one of the most common applications of PEGylation, PEGylation has also been used, albeit to a limited degree, to improve the bioavailability and ease of formulation of small molecule drugs having poor aqueous solubilities...