Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for CancerChromatin regulatorchromatin regulating proteininhibitorcancertherapyChromatin-regulating proteins modulate nucleosomeLuanUnivJieUnivZhangUnivPingyuUnivChuUnivZhiyongUnivChandraUnivJoyaUniv
cancer, and Ewing’s sarcoma. We will summarise recent studies on the development of PHGDH-inhibitors, highlighting their clinical potential as new therapeutics. It also wants to shed a light on some of the key limitations of the use of PHGDH-inhibitors in cancer treatment which are worth takin...
These results demonstrate that chemically unrelated virulence inhibitors may act in an antagonistic or additive manner, that their effect depends on the infection model applied, and that the attenuating effects of INP0010 in part relate to its ability to promote the SPI2 antagonist NO. 展开 ...
This article provides a comprehensive review and updates of ACC inhibitors, with a focus on their therapeutic application in metabolic syndromes and malignant diseases. The patent status of common ACC inhibitors is discussed. 展开 关键词: Acetyl-CoA carboxylases cancer fatty acid synthesis inhibitors ...
This article provides a comprehensive review and updates of ACC inhibitors, with a focus on their therapeutic application in metabolic syndromes and malignant diseases. The patent status of common ACC inhibitors is discussed. Keywords: Acetyl-CoA carboxylases, cancer, fatty acid synthesis, inhibitors...
To the best of our knowledge, this is the first report on the application of electrochemical sensing technology to investigate the interaction between atezolizumab and PD-1/PD-L1, as well as to screen PD-1/PD-L1 small molecule inhibitors. Additionally, the results of these two methods could ...
A number of small molecule inhibitors for FAK have been developed and in various phases of testing for cancer treatments. Overall, the intensive research ... J Zhao,JL Guan - 《Cancer & Metastasis Reviews》 被引量: 915发表: 2009年 Focal adhesion kinase and its signaling pathways in cell mig...
The potential role of inhibitors in calcium stone formation is not trivial: it may account for the fact that stones do not occur in the presence of significant urinary supersaturation. Furthermore, if stone formation could be attributed to a lack or deficiency of inhibitors, then their supplementa...
2) GSK-3βinhibitors 糖原合成酶-3β抑制剂 3) Glycogen synthase kinase3β,GSK-3β 糖原合成酶激酶3β(GSK-3β) 4) GSK-3β 糖原合成激酶-3β 1. Aim To explore the mechanisms of Curcumin which plays a role of protecting cells through regulating the activity ofGSK-3β. ...
6) non-peptidic inhibitors 非肽类抑制剂补充资料:二肽氨肽酶抑制剂 分子式:CAS号:性质:抑制二肽氨肽酶(EC3.4.14.1)活性的物质。二肽氨肽酶催化二肽(基)肽的水解,即作用于多肽的肽键水解后释放出二肽,故亦名二肽(基)转移酶。该酶参与血栓形成和止血的生化反应过程。该酶抑制剂如乙酰亮氨酸精氨醛等在...