Mariani R, Maffioli S (2009) Bacterial RNA polymerase inhibitors: an organized overview of their structure, derivatives, biological activity and current clinical development status. Curr Med Chem 16:430–454 View ArticleMariani R,Maffioli SI.Bacterial RNA polymerase inhibitors: an organized overview of...
Here, we report the discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase (RNAP) and exhibits antibacterial activity against drug-resistant bacterial pathogens: pseudouridimycin (PUM). PUM is a natural product comprising a formamidinylated...
At the specialist level, both non-invasive methods (e.g., urea breath test and serological assays) and invasive methods using biopsy samples (e.g., culture, histology, rapid urease test, and polymerase chain reaction (PCR)) can be selected. Helicobacter pylori infection activates local and ...
[细菌RNA聚合酶的]核心酶6) bacterial structure 细菌结构补充资料:聚合酶 分子式:CAS号:性质: 又称DNA聚合酶。系专司生物催化合成脱氧核糖核酸(DNA)和核糖核酸(RNA)的一类酶的统称。可分为以下几个类群:(1)依赖DNA的DNA聚合酶;(2)依赖RNA的DNA聚合酶;(3)依赖DNA的RNA聚合酶;(4)依赖RNA的RNA聚合酶。前...
RNA polymerasetranscription cycleThe Bacterial Chromosomedoi:10.1128/9781555817640.ch15Kati GeszvainRobert LandickGeszvain K, Landick R. 2005. The structure of bacterial RNA polymerase. In: Higgins N, editor. The bacterial chromosome. Washington, DC: ASM Press. pp 283-296....
Structure of the Bacterial RNA Polymerase Promoter Specificity σ Subunit The σ subunit is the key regulator of bacterial transcription. Proteolysis of Thermus aquaticus σA, which occurred in situ during crystallization, reveals three domains, σ2, σ3, and σ4, connected by flexible linkers. ...
Is the oncogene MYC upregulated or hyperactive? In the majority of human cancers, finding agents that target c-MYC has proved difficult. Here we report specific bacterial effector molecules that inhibit cellular MYC (c-MYC) in human cells. We show that u
Rifampicin, a broad-spectrum antibiotic, inhibits bacterial RNA polymerase. Here we show that rifampicin treatment of Escherichia coli results in a 50% decrease in cell size due to a terminal cell division. This decrease is a consequence of inhibition of transcription as evidenced by an isogenic ...
74Citations 90Altmetric Metrics Abstract In recent years, the alarming increase of antibiotic resistance, compounded by the simultaneous decrease in development of new antibiotics, has created serious concerns for public health. Moreover, current antibiotics also target the beneficial commensal microbes (...
产品名称 细菌RNA提取试剂盒|MolPure® Bacterial RNA Kit 产品规格 50T 用途范围 仅做科研,不用于临床 是否进口 否 加工定制 否 商品货号 19301ES 商品规格 50T 生产厂家 翌圣生物科技(上海)股份有限公司 规格编码 19301ES50 最小起订量 1.00 发货地 上海 售卖区域 全国 可售卖地 北京;天津;河...