scf-complex 例句 释义: 全部 更多例句筛选 1. SCF complex is a very important ubiquitin E3 ligase which has been exploited very well in plants. SCF复合体是一种非常重要的E3泛素连接酶,在植物中研究的最为深入。 www.chinagene.cn© 2025 Microsoft 隐私声明和 Cookie 法律声明 广告 帮助 反馈...
7 Zemla, A., Thomas, Y., Kedziora, S., Knebel, A., Wood, N.T., Rabut, G., and Kurz, T. (2013). CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Nat. Commun. 4, 1641. https://doi.org/10. 1038/ncomms2628.8 Wu, S., Zhu, W., Nhan, T., Toth...
SCF complex F-box protein MET30 (MET30)In vitro studies identified a small molecule inhibitor of the MET30 E3 ubiquitin ligase that could be used as an adjuvant to increase the antiproliferative activity of Rapamune. Further details on the research, next steps and licensing status are discussed...
complex. Each of the SCF complexes is composed of 4 subunits: Skp1, Cul1/Cdc53, Roc1/Rbx1/Hrt1, and an F-box protein (4). Cul1 serves as a scaffold and interacts with Rbx1 at its carboxyl terminus to recruit ubiquitin-conjugated E2 (4), while the amino terminus of ...
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In cases in which an SCF complex is overactive, the inhibition of SCF-mediated degradation can be achieved via competitive inhibition between substrate and F-box protein, allosteric inhibition that disrupts the interaction between substrate and F-box protein, or via the inhibition of SCF complex as...
We have provided evidence indicating a role for an SCFSlmb complex in elimination of E2F during S phase in Drosophila. We first demonstrated that mouse Cul1 overexpression has a dominant negative effect on SCF function in the wing imaginal disc resulting in apoptotic cell death leading to a small...
protein 1/2 (尾-TrCP1/2) F-box protein-containing SKP1/Cul1/F-box protein (SCF) complex (SCF) as an E3 ubiquitin ligase for Wee1A ubiquitination... Watanabe N,Arai H,Nishihara Y,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 656...
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In addition we show that blocking the activity of the 26S proteosome results in the accumulation of cyclin D1 and D3, that both D-type cyclins are ubiquitinated and associate with Cul-1, a component of the SCF ubiquitin ligase complex. Finally, we show that the coordinated elevation of ...