Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle 2005;4:1230-1232. [PubMed: 16123585]Benmaamar R, Pagano M: Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase. Cell Cycle 2005, 4 (9) : 1230–1232....
SCF复合物是一类E3泛素化连接酶,通过泛素化的催化促进蛋白酶体降解。细胞周期依赖泛素,SCF复合物在调节这一过程中起着不可或缺的作用。 罗伯托皮拉斯 泛素连接酶还通过26S蛋白酶体刺激细胞周期蛋白的降解来调节泛素化。这一过程的失调可能导致正常细胞向癌细胞的渐进转化。 细胞分裂(有丝分裂)发生在以下几个阶段,每...
Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer 来自 Springer 喜欢 0 阅读量: 31 作者:A Russell,MA Thompson,J Hendley,L Trute,J Armes,D Germain 摘要: D-type cyclins are important cell cycle regulators that promote cellular proliferation in ...
Cul1 is a core component of the evolutionarily conserved SCF-type ubiquitin ligases that target specific proteins for destruction. SCF action contributes to cell cycle progression but few of the key targets of its action have been identified. We found th
SCF complex potentially has a wide network of substrates because of the fact that it can bind with as many as 70 F-box proteins.18 Also, most of its known substrates, such as b-catenin, P21, P27 and cyclin E, are involved in regulation of the cell cycle.37 It is believed that in...
Mitotic regulation of the human anaphase‐promoting complex by phosphorylation C. (2004) APC/C and SCF: controlling each other and the cell cycle. Curr. Biol. 14 , R787–R796.Vodermaier HC. APC/C and SCF: controlling ... Kraft,C. - 《Embo Journal》 被引量: ...
ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C). Anaphase is the phase of mitosis during which condensed chromosomes separate into sister chromatids and move along the mitotic spindles to opposite poles of the cell. The APC/C is a multi-subunit E3 ubiquitin ligase with at least two alternative form...
In summary, we show that a cell-cycle-regulated SCF complex is regulated by the kinase PLK4, and that this in turn restricts centrosome re-duplication through degradation of the centriolar protein HsSAS-6. 展开 关键词: Cell-Cycle C-Elegans Centriole Protein Suppressor Degradation Family Box ...
The first crystal structure of a core SCF complex has been determined to 3.2 Å. Together with previous data obtained for RING E3-E2 and Skp1-Skp2 adaptor complexes, the structure provides substantial insight into SCF-mediated protein modification by ubiquitin, a process that regulates protein ...
DT204 stabilized p27, reduced myeloma viability, synergistically enhanced the anti-myeloma effect of BTZ and prevented Skp2 incorporation into the SCFSkp2 complex. DT204 was not toxic to inactive or phytohemagglutinin-activated peripheral blood mono- nuclear cells and promoted cell cycle arrest (...