[11]Wang J,Park J.S,WeiYet al.TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP andC/EBPa interactionJI.Molecular Cell201351:211-225 [12] Catzavelos C,Bhattacharya N,Ung YC,et al.Decreased levels ofthe cell-cycle inhibitor p27 Kiplprotein:prognostic implications in ...
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 428:194-198.Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase...
The cell cycle, in particular, is highly regulated by the functions of the... JR Skaar,M Pagano - 《Current Opinion in Cell Biology》 被引量: 199发表: 2009年 Structure, function and mechanism of the anaphase promoting complex (APC/C) The complex molecular events r...
Progression through the cell cycle requires the activity of two ubiquitination complexes, the Skp1—cullin—F-box-protein complex (SCF) and the anaphase-promoting complex/cyclosome (APC). Observations in the past year have revealed unexpected similarities between the \{SCF\} and the \{APC\} and...
Cell cycle regulatory E3 ubiquitin ligases as anticancer targets The ubiquitin-proteasome pathway is involved in various biological processes. Several oncogenic E3 ligases target tumor suppressor proteins for ubiquitin-m... TR Pray,F Parlati,J Huang,... 被引量: 0发表: 2002年 E3 Ubiquitin Ligases...
In vitro studies using human DP progenitors revealed a significant increase in cell proliferation after100 nM SCF application, explained by a 2-fold upregulation in cyclin D3 and FGF2 cell cycle regulators, and a 7-fold increase in CDK4 expression. DP cell migration in the presence of SCF ...
Ubiquitin-mediated proteolysis is a key regulatory process in cell cycle progression. The Skp1-Cul1-F-box (SCF) and anaphase- promoting complex (APC) ubiquitin ligases target numerous components of the cell cycle machinery for destruction. Throughout the cell cycle, these ligases cooperate to maint...
Diehl, SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough, Cell Cycle 7 (2008) 2983-2986.O. Barbash, J. A. Diehl, SCF(Fbx4/aB-... Olena Barbash,J Alan Diehl 被引量: 48发表: 2008年 Lysine 269 is essential for cyclin D1 ubiquitylation by the SCFFbx4/αB-crystallin...
Adam10 haploinsufficiency causes freckle‐like macules in Hairless mice pigmentationfrecklesCd44Summary The Hairless nuclear receptor co‐repressor is required for hair follicle regeneration during the hair cycle. The classical ... G Tharmarajah,L Faas,K Reiss,... - 《Pigment Cell & Melanoma Research...
Cell cycle checkpoints, such as anaphase promoting complex/cyclosome/cell cycle switch 52 A2 (APC/CCCS52A2), strictly control the low proliferation rate of QC cells. Although APC/CCCS52A2plays a critical role in maintaining QC cell division, the molecular mechanism that regulates its activity ...