Conclusion Carbenoxolone enhances the inhibitory effect of RSL3 on the proliferation, invasion and migration of cisplatin-resistant testicular cancer cells by promoting RSL3-induced ferroptosis. Keywords: testicular cancer; RSL3; carbenoxolone; proliferation; invasion; migration; ferroptosis 睾丸癌是 20...
RSL3货号T3646,别名RSL3 1S或1S,3R-RSL3,是谷胱甘肽过氧化物酶4(GPX4)的抑制剂,可抑制阻断 GSH 合成的半胱氨酸/谷氨酸氨基酸转运系统,是一种铁死亡(ferroptosis)激活剂。 Erastin货号T1765,是一种通过抑制细胞表面胱氨酸/谷氨酸逆向转运蛋白(System Xc-),导致GPX4的失活引发铁死亡的铁死亡(ferroptosis)激活剂。该...
关键词 急性白血病;耐药细胞;铁死亡;谷胱甘肽过氧化物酶4;活性氧 中图分类号 R733.71 文献标识码 A :10.19746/ki.issn1009-2137.2021.04.014 doi Effect and Involved Mechanism of RSL3-induced Ferroptosis in Acute Leukemia Cells MOLM13 ...
TargetMol明星分子——RSL3& Erastin RSL3货号T3646,别名RSL3 1S或1S,3R-RSL3,是谷胱甘肽过氧化物酶4(GPX4)的抑制剂,可抑制阻断 GSH 合成的半胱氨酸/谷氨酸氨基酸转运系统,是一种铁死亡(ferroptosis)激活剂。 Erastin货号T1765,是一种通过抑制细胞表面胱氨酸/谷氨酸逆向转运蛋白(System Xc-),导致GPX4的失...
产品活性:RSL3 ((1S,3R)-RSL3) 是一种谷胱甘肽过氧化物酶 4 (GPX4) 的抑制剂 (ferroptosis 激动剂),可降低 GPX4 的表达,诱导头颈部癌细胞的肥大性死亡。在 HN3 耐受细胞中,可增加 p62 和 Nrf2 的蛋白水平,使 Keap1 灭活。 体外:RSL3 (0-8 μM,72 小时) 有效降低 HN3 细胞的活力,HN3 中的 IC50...
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer. Front Pharmacol. 2018;9:1371. Published 2018 Nov 22. doi:10.3389/fphar.2018.01371[4] Yang Y, Luo M, Zhang K, et al. Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis ...
SCD1目的:肺癌是世界范围内癌症相关死亡的主要原因,但其治疗研究一直没有突破性的进展,近些年,铁死亡(Ferroptosis)在抗肿瘤方面的深入研究为肺癌的治疗和预防带来了新的前景.TIGAR(TP53-induced glycolysis and apoptosis regu-lator)作为p53诱导的糖酵解和凋亡调节蛋白,在多种恶性肿瘤中表达上调并在其中发挥促肿瘤生长...
ApoptosisEndogenous MetaboliteFerroptosisInfluenza VirusReactive Oxygen SpeciesROSTNF ¥ 326 现货 规格 数量 客户已引用 L-Cystine 胱氨酸, L-胱氨酸, Cystine Acid, cystine T2O273356-89-3 L-Cystine (Cystine Acid) 是一种从半胱氨酸氨基酸硫醇侧链氧化获得的含硫衍生物。它起到抗氧化剂的作用,保护组织免受...
[1]. Sui X, et al. RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer. Front Pharmacol. 2018 Nov 22;9:1371. [2]. Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med....
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462.[2]. Romani P, et al., Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell ...