Novel ideas for the prevention and treatment of related diseases have been provided by ferroptosis, which has become a focus of research in recent years. This review introduces the underlying mechanisms related
Recent research has revealed that ferroptosis can be invoked and propagated by excessive lipid peroxidation at phospholipid-membrane-bound organelles, namely the mitochondria,26endoplasmic reticulum,27and Golgi apparatus.28Since the peroxisome can synthesise and incorporate PUFA into the phospholipid membrane,...
However, recent research regarding pancreatic adenocarcinoma and colon carcinoma have shown that the anticancer activity of sorafenib mainly depends on the inhibition of SLC7A11/GPX4 activity to induce ferroptosis; the activation of ferroptosis in turn promotes the anticancer effect of sorafenib [124, ...
In recent years, a growing body of research have shown that the molecular mechanisms and signaling pathways of ferroptosis may be closely related to female infertility diseases. It has been generally recognized that iron overload in the peritoneal fluid from infertile patients enhances ferroptosis ...
Targeting p53 pathways: mechanisms, structures, and advances in therapy 2023, Signal Transduction and Targeted Therapy FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations 2023, Nucleic Acids Research View all citing articles on Scopus ...
Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since its discovery in 2012, extensive research has demonstrated its pivotal roles in tumorigenesis, metastasis and cancer therapy. The tumor microenvironment (TME) is a complex ecosy...
There are a vast array of non-coding RNAs in the body, and a growing number of studies have demonstrated that they can affect numerous molecular targets and act as oncogenes or tumor suppressors [59]. In recent years, the spotlight in oncology research has focused on micro RNA (miRNA), ...
it should be noticed that they are also known as an endogenous anti-oxidative factor and not specific to ferroptosis [188]. Current studies on both NRF2 and HO-1 in the regulation of diabetic CVDs seem to be dichotomous, and more research may help to explore the regulatory mechanism of NRF2...
Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option that has attracted much attention due to its low immunogenicity, low toxicity, and ability to penetrate b
Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discov. 2022;8:501. 128. Kim R, Taylor D, Vonderheide RH, Gabrilovich DI. Ferroptosis of immune cells in the tumor microenvironment. Trends Pharmacol Sci. 2023;44:542–52. 129. Li Q, Zhong X, Yao W, Yu J, Wang C,...