Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities in pursuit to reveal the mechanism and key targets of ferroptosis because ...
In this review, we provide an overview of the known mechanisms that regulate the sensitivity of cancer cells to ferroptosis and the research progress of ferroptosis-related drugs (western medicine, traditional Chinese medicine, and nanomedicine), as well as the relationship between ferroptosis and ...
Recent progress in ferroptosis inducers for cancer therapy Adv Mater, 31 (51) (2019), Article e1904197 Google Scholar [134] S.J. Dixon, K.M. Lemberg, M.R. Lamprecht, R. Skouta, E.M. Zaitsev, C.E. Gleason, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death Cel...
In the past few decades, iron-based nanomaterials have been widely studied due to high terrestrial abundance, unique optical and electromagnetic properties, and good biocompatibility. Iron-based nanomaterials can be divided into two main categories: (1) one is iron-based nanocrystals, including iron ...
vesicles (EVs), mitochondrial DNA (mtDNA) discharge, tumor necrosis, cell death by iron accumulation (ferroptosis), cell bursts due to cytoplasmic swelling (oncosis), proinflammatory cell rupture (pyroptosis), phagocytosis and programmed cell death, which subsequently impact ctDNA detection [106]....
We highlight recent progress in the discovery of selective inhibitors, dual-target inhibitors, allosteric modulators, covalent inhibitors, proteolysis-targeting chimeras (PROTACs), and protein-protein interaction (PPI) modulators. Our goal is to provide insights into the prospective development and ...
Programmed cell death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes...
(GPX4). This imbalance leads to lipid peroxidation, which is further exacerbated by Fe2+through the Fenton reaction, generating a high concentration of reactive oxygen species (ROS) [9,11,12]. Ferroptosis has been implicated in a variety of multi-systemic diseases, including neurological disorders...
This can induce pyroptosis and ferroptosis instead of conventional apoptosis in tumor cells. Meanwhile, IR780-iodide (IR780), as an excellent phototherapy agent, can generate hyperthermia and generate a large amount of ROS to synergize with the CDT of Na2S2O8, with potential to overcome ...
J Nanobiotechnol (2020) 18:154 https://doi.org/10.1186/s12951-020-00713-3 Journal of Nanobiotechnology REVIEW Open Access Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment Gaofeng Liang1*, Haojie Wang1, Hao Shi2, Haitao Wang...