The hallmarks of ferroptosis. Annu Rev Canc Biol. 2019;3:35–54. Article Google Scholar Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520:57–62. Article CAS PubMed PubMed Central Google ...
The metabolic underpinnings of ferroptosis. Cell Metab. 32, 920–937 (2020). CAS PubMed Google Scholar Dixon, S. J. & Stockwell, B. R. The hallmarks of ferroptosis. Annu. Rev. Cancer Biol. 3, 35–54 (2019). Google Scholar Yang, W. S. et al. Regulation of ferroptotic cancer ...
FerroptosisIronLipid peroxidationPlacentaPregnancyCELL-DEATHIRON STATUSCANCERHALLMARKSZIP14Ferroptosis is a recently identified form of programmed cell death which is different from apoptosis, pyroptosis, necrosis, and autophagy. It is uniquely defined by redox-active iron-dependent hydroxy-peroxidation of ...
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene ex...
Consistently, the loss of GPX4 functionality, along with increased free iron availability and oxidation of PUFAs, were recently proposed to constitute the “Hallmarks of Ferroptosis,” or the three main events associated with the initiation of this pathway (Dixon and Stockwell, 2019). Of note, ...
Targeting cancer vulnerabilities with high-dose vitamin C 2019, Nature Reviews Cancer The hallmarks of ferroptosis 2019, Annual Review of Cancer Biology Recent advances in the application of vitamin E TPGS for drug delivery 2018, Theranostics View all citing articles on Scopus 8 Lead Contact ...
Angiogenesis, invasion, metastasis, and migration are the four hallmarks of cancer, and it has been shown that MMPs play a vital role in the degradation of cell adhesion molecules. Overexpressed MMPs in the extracellular environment of many malignancies make them a promising target for drug release...
Ferroptosis, a newly identified form of regulated cell death triggered by small molecules or specific conditions, plays a significant role in virus-associated carcinogenesis. However, whether tumours arising after high-risk HPV integration are associated with ferroptosis is unexplored and remains enigmatic...
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 2021;184:5309–37. Article PubMed PubMed Central CAS Google Scholar Jiang W, Pan S, Chen X, Wang Z, Zhu X. The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy. Mol ...
Patients with PPD demonstrate cognitive impairments that are hallmarks of bvFTD. In order to achieve optimal management, correctly diagnosing the onset of bvFTD in patients with a lifetime history of PPD is essential.In this investigation, twenty-nine participants exhibiting PPD were involved. check...