Ferroptosis is considered genetically and biochemically distinct from other forms of cell death. In this study, we examined whether ferroptosis shares cell death pathways with other types of cell death. When human colon cancer HCT116, CX‐1, and LS174T cells were treated with ferroptotic agents...
Ferroptosis is an iron-dependent, oxidative cell death, and is distinct from apoptosis, necrosis and autophagy. In this study, we demonstrated that lysosome disrupting agent, siramesine and a tyrosine kinase inhibitor, lapatinib synergistically induced cell death and reactive oxygen species (ROS) in ...
Radiation-induced brain injury (RBI) presents a significant challenge for patients undergoing radiation therapy for head, neck, and intracranial tumors. This review aims to elucidate the role of ferroptosis in RBI and its therapeutic implications. Specifically, we explore how ferroptosis can enhance the...
Ferroptosis, an iron-dependent form of regulated cell death that is induced by excessive lipid peroxidation, is morphologically and mechanistically distinct from apoptosis.4,5,6Current studies indicate that ferroptosis is mainly induced by peroxidation of phospholipids (PLs) that contain polyunsaturated fat...
Ferroptosis: a new perspective on the pathogenesis of radiation-induced cataracts doi:10.3389/fpubh.2024.1449216Frontiers in Public HealthYufu TangHongying LiangLixia SuXiangming XueJingming Zhan
(ROS). Therefore, this study aimed to investigate the role of ferroptosis in dextran sulfate sodium (DSS)-induced UC. The animal model was established and the molecular markers of ferroptosis were detected by using western blot. The results suggested that the expression of COX2 and ACSL4 was ...
s Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role of ACSL4 in the progression of ischemic stroke is unclear. Here, we found that ACSL4 expression was suppressed in ...
Erastin是铁死亡激活剂,与电压依赖的阴离子通道VDAC2和VDCA3结合,但Erastin处理会导致这些通道的降解。在这里,作者表明,Nedd4是在erastin处理后被诱导的,这导致了通道的泛素化和随后的降解。Nedd4的缺失限制了VDAC2/3的蛋白质降解,从而增加了癌细胞对Erastin的敏感性。通过了解Erastin诱导细胞抵抗的分子机制,我们可以...
Using TRIM21 gene knockout mice, we found that TRIM21 ablation has a strong protective effect in oxidative cardiotoxicity induced by doxorubicin and LAD ligation. We further found that the cardiac protective effect upon doxorubicin treatment is through the inhibition of ferroptosis both in vivo and ...
Amorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a newly defined form of programmed cell death that is implicated in myocardial diseases. Neverthe