Ferroptosis is considered genetically and biochemically distinct from other forms of cell death. In this study, we examined whether ferroptosis shares cell death pathways with other types of cell death. When human colon cancer HCT116, CX‐1, and LS174T cells were treated with ferroptotic agents...
The cell viability analysis [20], [21], [22] showed that erastin-induced ferroptosis was inhibited in CDO1-slienced GC cells (Figure 1G). In contrast, overexpression of CDO1 promoted erastin-induced ferroptosis (Supplementary Figure 1C). Based on these findings, we suggest that erastin can ...
we generatedATF3-knockout (KO) RPE cells with the CRISPR/Cas9 tool (Fig.2e). While the normal epithelial cells were sensitive to erastin (Fig.2f), knockout ofATF3expression dramatically suppressed erastin-induced ferroptosis and lipid peroxidation (...
铁死亡(ferroptosis)是一种铁依赖的、脂质过氧化物累积的新型细胞死亡方式,与肿瘤的发生、发展和耐药密切相关。自从铁死亡被发现以来,就以一己之力掀起研究狂潮,至今热度不减,俨然成为医学科研领域热门的研究方向,也是近些年国自然基金热点资助项目。 文章题目:Cetuximab promotes RSL3-induced ferroptosis by suppressing th...
Ferroptosis is an iron-dependent, oxidative cell death, and is distinct from apoptosis, necrosis and autophagy. In this study, we demonstrated that lysosome disrupting agent, siramesine and a tyrosine kinase inhibitor, lapatinib synergistically induced c
The Glucocorticoid-induced posterior subcapsular cataracts (GIC) is a common complication of patients received glucocorticoid treatment in clinic. We find that dexamethasone (DEX) induces lens epithelial cells' ferroptosis. DEX treatment increases intracellular ferroptosis signatures in lens epithelial cell ...
Collectively, our results suggest that ferroptosis-mediated Sesn2 induction is dependent on Nrf2 and plays a protective role against iron overload and ferroptosis-induced liver injury. 展开 关键词: Ferroptosis Hepatocytes Liver injury Nrf2 Sestrin2 ...
Fig. 1. Ferroptosis was involved in DSS-induced UC. (A)Evaluation of thebody weightafter treatment;(B)Colon length analysis after treatment. Colon length is represented as a ratio (cm/g) relative to the starting weight of mice prior to DSS administration;(C)Representative H&E staining of ...
Background and purpose Inflammation and ferroptosis in astrocytes can be induced by external injuries, which results in excessive production of inflammatory factors and further injury on neurons. Alleviating ferroptosis might be an effective way to protect the brain from external injuries. The present st...
Otitis media (OM) is a common disease that can cause hearing loss in children. Currently, the main clinical treatment for OM is antibiotics, but the overuse of antibiotics might lead to bacterial resistance, which is a worldwide public health challenge.